DIABETES RES CLIN PR:糖尿病显著增加抑郁风险

　　意大利的一项荟萃研究提示，糖尿病与抑郁风险显著增加相关。文章认为糖尿病与抑郁症相关的病理机制值得进一步探讨。相关论文2012年12月26日在线发表于《糖尿病研究与临床实践》杂志（Diabetes Research and Clinical Practice）。

　　该荟萃研究使用关键词“糖尿病和抑郁或糖尿病和抗抑郁药”检索Medline，选择那些评价有或无糖尿病的个体与抑郁症发生风险的纵向研究。共检索出1898项相关研究，其中16项纳入荟萃研究，包括497223个样本，平均随访5.8年，有42633例抑郁发作。与非糖尿病组相比，糖尿病组的受试者抑郁年发生率更高（1.4% vs 1.6%，p<0.001），未经校正和校正后的危险度分别为1.29（95%可信区间1.18-1.40，p<0.001）和1.25（95%可信区间1010-1.44，p=0.001）。

与糖尿病相关的拓展阅读：

• J Diabetes：糖尿病治疗模式变革即将到来？
• DIABETES CARE：1型糖尿病患者分娩后血糖和体重增高
• PLoS Genet:面对2型糖尿病，胖瘦是否有区别？
• Diabetes Care;肾病增高糖尿病视网膜病变风险
• BMC Cancer：糖尿病恶化乳腺癌患者预后
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Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies

Aim

The present meta-analysis is aimed at the assessment of the risk of incident clinical depression and/or depressive symptoms in patients with diabetes.

Methods

A Medline search was performed on December 30th, 2011, using the search string: “diabetes AND (depression OR antidepressant)”, selecting longitudinal studies that assessed the risk of incident depression in subjects with or without diabetes. Study design and characteristics were verified for each study. A meta-analysis was performed for unadjusted and adjusted risk ratios of incident depression in subjects with diabetes using a random effect model. Additional analyses were performed to assess heterogeneity, publication bias and specific hazard ratios for several possible confounders.

Results

Of the 1898 retrieved studies, 16 were included in the meta-analysis, enrolling 497,223 subjects, with a mean follow-up of 5.8 years and 42,633 cases of incident depression. A higher incidence of depression was found in diabetic subjects (1.6% vs 1.4% yearly), with unadjusted and adjusted risk [95% confidence interval] of 1.29 [1.18–1.40] (p<0.001) and 1.25 [1.10–1.44] (p=0.001), respectively.

Conclusions

Diabetes is associated with a significantly increased risk for depressive symptoms. Pathogenetic mechanisms connecting diabetes with depression deserve further exploration.