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Stroke:缺血性卒中和冠心病史患者的颈动脉斑块特征研究

2016-07-24 phylis 译 MedSci原创

背景:由于动脉粥样硬化是一种全身性疾病,1个位置上存在和组成可能与远端缺血事件有关。研究者探讨颈动脉粥样硬化壁厚,狭窄,斑块组成是否与缺血性卒中和冠状动脉心脏病(CHD)相关。方法:以人口为基础的鹿特丹研究,1731无症状的参与者(平均年龄为72.4±9.1岁, 55%为男性)进行了双侧颈动脉磁共振成像。研究者评估颈动脉壁厚度、狭窄和斑块组成,斑块内出血,脂质和钙化。磁共振成像后,对缺血性卒中和冠

背景:由于动脉粥样硬化是一种全身性疾病,因此,动脉粥样硬化可能与远端缺血事件有关。研究者探讨颈动脉粥样硬化厚壁、狭窄、斑块组成是否与缺血性卒中和冠状动脉心脏病(CHD)相关。

方法:以人口为基础的鹿特丹研究,1731无症状的参与者(平均年龄为72.4±9.1岁, 55%为男性)进行了双侧颈动脉磁共振成像。研究者评估颈动脉壁厚度、狭窄和斑块组成,斑块内出血、脂质和钙化。磁共振成像后,对缺血性卒中和冠心病史进行了评估。这项研究是由机构审查委员会批准的,所有参与者都知情同意。校正年龄和传统心血管风险因素,应用Logistic回归分析研究斑块的特点和临床事件之间的性别特异相关性。

结果:研究发现,颈动脉狭窄和斑块内出血与男性缺血性脑卒中相关,而与女性缺血性卒中不相关(男性:狭窄每增加10%的OR:1.17 95% CI,1.06-1.30 ;斑块内出血为2.39 [ 95% CI,1.32-4.35 ])。在男性和女性中,颈动脉狭窄与冠心病相关(男性:每增加10%OR 为1.12 [ 95% CI, 1.04-1.21 ];女性:OR,1.17 [ 95% CI,1.03-1.34 ])和颈动脉壁厚度与冠心病相关(男,1.20 [ 95% CI,1.03-1.39 ];女性:OR,1.21 [ 95% CI,0.88-1.65 ])。斑块组成与冠心病不相关。

结论:颈动脉斑块厚度和狭窄与缺血性卒中和冠心病史有关,颈动脉斑块内出血与缺血性卒中相关,但不与冠心病相关,为心血管事件的发病机制提供了新的见解。

原始出处:

Selwaness M, Bos D, et al. Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease. Stroke. 2016 Jun


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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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