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Clin Gastroenterology H:患有食管腺癌的年轻人晚期肿瘤发生风险更高并且存活时间更短

2019-08-03 不详 MedSci原创

年轻人群的肥胖率正在增加。Barrett食管与中心性肥胖有关,因此本项研究调查了年轻患者食管腺癌(EAC)的发生情况,并将其与年龄较大的患者进行了比较,以确定其表现和生存时间特征的差异。

背景与目的
年轻人群的肥胖率正在增加。Barrett食管与中心性肥胖有关,因此本项研究调查了年轻患者食管腺癌(EAC)的发生情况,并将其与年龄较大的患者进行了比较,以确定其表现和生存时间特征的差异。

方法
研究人员对2009年至2012年接受EAC诊断的682例患者进行了单中心回顾性研究。使用Cox比例风险模型来比较年轻人(小于50岁,n = 105),中年( 51-70岁,n = 383),年龄较大(70岁以上,n = 194)的患者。使用分析变量的χ2分析和连续变量的方差分析来比较基线特征。

结果
与中年组和老年组相比,年轻组中较高比例的患者出现III期EAC(43.8%)或IV期EAC(33.3%)(中年组为:III期39.7%,IV期21.7%; P <.001),(老年组为:III期30.4%,IV期20.6%; P <.001)。年轻组诊断后的平均生存时间为4±4.2岁,而中年组为5±3.9岁(P = .03)。未调整模型显示,与中年组相比,青年组死亡风险增加(风险比,1.5; 95%CI,1.1-1.9; P= .004)。

结论
本项研究发现年轻患者(年龄小于50岁)比中年患者有更高比例的食管腺癌发生率; 与年龄较大的EAC患者相比,年轻患者的生存期也更短。

原始出处:

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    2020-04-06 许安
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06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504748, encodeId=f1861504e481b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Aug 05 06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512290, encodeId=04cb1512290fb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, 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  5. 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06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504748, encodeId=f1861504e481b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Aug 05 06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512290, encodeId=04cb1512290fb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, topicName=食管腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a7410453390, createdName=ms7899726347904398, createdTime=Mon Aug 05 06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2020-04-20 heli0118
  6. 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  7. 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06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504748, encodeId=f1861504e481b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Aug 05 06:45:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512290, encodeId=04cb1512290fb, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, 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    2019-08-05 zhouqu_8
  8. 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