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Nutrition:2型糖尿病患者限盐并非** 这种情况下另当别论!

2017-07-10 徐晓涵 吴刚 环球医学

虽然钠葡萄糖协同转运蛋白2(SGLT2)抑制剂会增加钠排泄入尿中,但低钠血症仍然罕见,随之带来不良反应。2017年5月,发表在《Nutrition》的一项研究调查了2型糖尿病患者中,SGLT2抑制剂给药后,盐(钠离子)的摄入是否会影响血清钠水平。

虽然钠葡萄糖协同转运蛋白2(SGLT2)抑制剂会增加钠排泄入尿中,但低钠血症仍然罕见,随之带来不良反应。2017年5月,发表在《Nutrition》的一项研究调查了2型糖尿病患者中,SGLT2抑制剂给药后,盐(钠离子)的摄入是否会影响血清钠水平。

本研究中,研究人员在20名2型糖尿病患者中,检测了SGLT2抑制剂给药后,盐(钠离子)的摄入是否会影响血清钠水平。

患者每个月都进行定期的随访检查,检查内容包括血压、血清钠和糖化血红蛋白,并根据Tanaka公式评估每天钠的摄入。研究人员对坎格列净(100mg/d)开始前和开始后的样本进行了比较。数据表明,SGLT2抑制剂给药后,血清钠水平的改变和每天盐的摄入具有显着的正相关性。

这表明,减少每天盐摄入同时进行SGLT2抑制剂治疗的患者可出现低钠血症。虽然限盐对于2型糖尿病高血压患者的治疗来说是重要的,但是当给予SGLT2抑制剂的时候,应该仔细考虑每天盐的摄入。

原始出处:

Eijiro Yamada, Aya Osaki, et al. Serum sodium ion level influenced by daily salt intake after administration of sodium-glucose cotransporter 2 inhibitors. Nutrition. Available online 31 May 2017 https://doi.org/10.1016/j.nut.2017.05.008

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1661585, encodeId=8d331661585e4, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Apr 13 01:38:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=223695, encodeId=0fc422369551, content=学习谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Jul 19 05:20:15 CST 2017, time=2017-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221253, encodeId=76b2221253f9, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jul 12 06:49:37 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383324, encodeId=0ffd1383324ca, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 12 06:38:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474253, encodeId=a93d14e425319, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 12 06:38:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220782, encodeId=7010220e82e0, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Jul 10 19:13:36 CST 2017, time=2017-07-10, status=1, ipAttribution=)]
    2017-07-19 lou.minghong

    学习谢谢分享!

    0

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    2017-07-12 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

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    2017-07-10 虈亣靌

    讲解的非常好,值得学习

    0

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