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JAHA:射血分数改善型心衰的临床特征研究

2019-03-10 不详 MedSci原创

许多射血分数降低型心衰(HFrEF)患者会经历左室射血分数(LVEF)的提高和改善。对于射血分数改善型心衰(HFiEF)患者的临床特征和预后尚不清楚。KorAHF 临床研究纳入了5625名因急性心衰住院的患者,其中5103名患者基线水平有超声心动图检查,2302名在随访12个月后有超声心动图检查。患者的心衰可以分为固执型HFrEF(随访一年后LVEF ≤40%),HFiEF(基线水平LVEF ≤4

许多射血分数降低型心衰(HFrEF)患者会经历左室射血分数(LVEF)的提高和改善。对于射血分数改善型心衰(HFiEF)患者的临床特征和预后尚不清楚。

KorAHF 临床研究纳入了5625名因急性心衰住院的患者,其中5103名患者基线水平有超声心动图检查,2302名在随访12个月后有超声心动图检查。患者的心衰可以分为固执型HFrEF(随访一年后LVEF ≤40%),HFiEF(基线水平LVEF ≤40%,随访一年后提高至40%以上),LVEF中等的心衰(LVEF在40%和50%之间)和射血分数保留型心衰(LVEF ≥50%),主要终点事件是4年的全因死亡率。在1509名HFrEF患者中,720 (31.3%)名诊断为 HFiEF。低龄、女性、新发心衰、高血压房颤和贝塔受体阻滞剂的使用是HFiEF的阳性预测因素,糖尿病和缺血性心脏病是HFiEF的阴性预测因素。经过4年时间的随访,HFiEF患者的死亡率低于固执型HFrEF患者,β-阻滞剂,而不是肾素-血管紧张素系统抑制剂或盐皮质激素受体拮抗剂,与降低全因死亡率相关(HR:0.59; 95% CI, 0.40–0.87; P=0.007)。

研究结果显示,射血分数改善型心衰是一种特殊类型的心衰,其预后要好于其他类型的心衰。β-阻滞剂的使用对这类患者有益处。

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    2019-06-03 一天没事干

    很好的学习机会

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    2019-05-06 一天没事干

    很好的学习机会

    0

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    2019-03-12 zhaohui6731

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