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Clin Nutr:喝咖啡能抗炎?

2016-10-30 MedSci MedSci原创

溶血磷脂酰胆碱(LysoPC)是氧化低密度脂蛋白(LDL)的病理成分;一些研究表明,该物质可以在体外具有促炎作用。然而,在咖啡中发现的生物活性化合物,如酚酸类物质,可能会抑制低密度脂蛋白的氧化。本研究的目的是,评估成人咖啡摄入量和血浆LysoPC水平的关系。数据来自“圣保罗健康调查(ISA-Capital)”,是一项在圣保罗进行的以人群为基础的横断面调查,纳入169例20岁或以上的参与者。参与者被

溶血磷脂酰胆碱(LysoPC)是氧化低密度脂蛋白(LDL)的病理成分;一些研究表明,该物质可以在体外具有促炎作用。然而,在咖啡中发现的生物活性化合物,如酚酸类物质,可能会抑制低密度脂蛋白的氧化。本研究的目的是,评估成人咖啡摄入量和血浆LysoPC水平的关系。

数据来自“圣保罗健康调查(ISA-Capital)”,是一项在圣保罗进行的以人群为基础的横断面调查,纳入169例20岁或以上的参与者。参与者被分为三组:不摄入咖啡(0 mL/day-G1),咖啡摄入量低(≤100 mL/day-G2),咖啡摄入量高(>100 mL/day-G3)。

校正年龄、性别、家庭人均收入、吸烟、运动、体重指数、总能量摄入、使用药物、蔬菜和水果的摄入和咖啡因的摄入后,通过多元线性回归分析,评估咖啡摄入量和血浆LysoPC水平的联系。

结果表明,G3组的参与者的LysoPC水平明显低于G1组参与者,lysoPC C16:1 (β = −0.56; p = 0.014),C18:1 (β = −2.57; p = 0.018),C20:4 (β = −1.14; p = 0.037)。相反,C16:0/C16:1和C18:0/18:1则是G3组参与者更高(β = 5.04; p = 0.025和β = 0.28; p = 0.003)。

不同咖啡摄入量的参与者的LysoPC组分和含量存在差异,摄入咖啡可能对炎症和氧化过程有益。

原始出处:


Andreia Machado Miranda,et al.The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach.Clin Nutr.2016.10.27


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  1. [GetPortalCommentsPageByObjectIdResponse(id=154786, encodeId=e5e2154e8685, content=很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Thu Nov 10 14:33:23 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154250, encodeId=a47615425018, content=观点非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Nov 08 07:52:05 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153968, encodeId=17cf15396822, content=观点很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Nov 07 08:10:18 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152263, encodeId=452d1522636d, content=第一次听说的~, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160923/IMG57E54D670B3C08868.jpg, createdBy=e90b1956497, createdName=Carlos007, createdTime=Sun Oct 30 22:17:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152203, encodeId=9b9e15220396, content=天天喝!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Oct 30 13:08:18 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152192, encodeId=d0ac152192e2, content=真的假的?, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sun Oct 30 12:00:34 CST 2016, time=2016-10-30, status=1, ipAttribution=)]
    2016-11-10 幸运8355

    很好的

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=154786, encodeId=e5e2154e8685, content=很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Thu Nov 10 14:33:23 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154250, encodeId=a47615425018, content=观点非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Nov 08 07:52:05 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153968, encodeId=17cf15396822, content=观点很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Nov 07 08:10:18 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152263, encodeId=452d1522636d, content=第一次听说的~, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160923/IMG57E54D670B3C08868.jpg, createdBy=e90b1956497, createdName=Carlos007, createdTime=Sun Oct 30 22:17:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152203, encodeId=9b9e15220396, content=天天喝!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Oct 30 13:08:18 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152192, encodeId=d0ac152192e2, content=真的假的?, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sun Oct 30 12:00:34 CST 2016, time=2016-10-30, status=1, ipAttribution=)]
    2016-11-08 幸运8355

    观点非常好

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=154786, encodeId=e5e2154e8685, content=很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Thu Nov 10 14:33:23 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154250, encodeId=a47615425018, content=观点非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Nov 08 07:52:05 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153968, encodeId=17cf15396822, content=观点很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Nov 07 08:10:18 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152263, encodeId=452d1522636d, content=第一次听说的~, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160923/IMG57E54D670B3C08868.jpg, createdBy=e90b1956497, createdName=Carlos007, createdTime=Sun Oct 30 22:17:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152203, encodeId=9b9e15220396, content=天天喝!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Oct 30 13:08:18 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152192, encodeId=d0ac152192e2, content=真的假的?, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sun Oct 30 12:00:34 CST 2016, time=2016-10-30, status=1, ipAttribution=)]
    2016-11-07 幸运8355

    观点很好

    0

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    2016-10-30 Carlos007

    第一次听说的~

    0

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    2016-10-30 1dd8c52fm63(暂无匿称)

    天天喝!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=154786, encodeId=e5e2154e8685, content=很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Thu Nov 10 14:33:23 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154250, encodeId=a47615425018, content=观点非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Nov 08 07:52:05 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153968, encodeId=17cf15396822, content=观点很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Nov 07 08:10:18 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152263, encodeId=452d1522636d, content=第一次听说的~, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160923/IMG57E54D670B3C08868.jpg, createdBy=e90b1956497, createdName=Carlos007, createdTime=Sun Oct 30 22:17:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152203, encodeId=9b9e15220396, content=天天喝!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Oct 30 13:08:18 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152192, encodeId=d0ac152192e2, content=真的假的?, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sun Oct 30 12:00:34 CST 2016, time=2016-10-30, status=1, ipAttribution=)]
    2016-10-30 上邪zyy

    真的假的?

    0

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