Baidu
map

JACC:降糖药物与心血管关系十大认识:二甲双胍可能是**对心血管有益的降糖药物

2017-06-01 钟巧青 张国刚 中国循环杂志

近日,JACC发表文章强调了降糖药物对心血管系统的影响作用,以下是该文的十大要点。

近日,JACC发表文章强调了降糖药物对心血管系统的影响作用,以下是该文的十大要点。



1 FDA以及欧洲药品管理局强制推行了一项制度,即所有新型降糖药物必须有前瞻、随机、对照的临床试验证明其心血管安全性。

2 基于一些临床终点事件的研究,部分磺脲类药物已经因为增加心血管事件风险而被FDA黑框警告。

3 迄今为止,只有二甲双胍是唯一可能有心血管获益的降糖药物。

4 二甲双胍不会引起体重增加,也不增加低血糖的风险,有多年使用安全的证据,且价格低廉,适合作为首选并可广泛应用于糖尿病合并有心血管疾病患者。

5 近期有部分研究表明,有些治疗2型糖尿病的新药能降低合并心血管疾病的糖尿病患者的心血管事件。

6 SGLT2抑制剂empagliflozin能显着和迅速减少心血管死亡和心衰患者的入院率,这可能与该药能改善血流动力学以及改善代谢机能有关。

7 GLP-1受体拮抗剂liraglutide和 semaglutide也能降低心血管死亡风险,极大地减少心血管事件,但显效较慢且未能降低心衰的风险。

8 心血管病学专家应熟悉降糖药物的心血管获益,因为很多2型糖尿病的患者合并有心血管疾病,而这些患者更应该从治疗中获益。

9 心血管病学专家也应该在心血管疾病患者中广泛筛查2型糖尿病的患者,界定这些目标人群,让这些患者尽早的从上述治疗中获益。

10 与其他心脏疾病的防治团队一样,心血管病学专家、全科医生以及糖尿病学专家应该共同协作,以期给予心血管病易患2型糖尿病的人群更为优化的治疗方案。

原始出处:

Naveed Sattar, Mark C. Petrie, et al. Novel Diabetes Drugs and the Cardiovascular Specialist. Journal of the American College of Cardiology.Volume 69, Issue 21, May 2017 DOI: 10.1016/j.jacc.2017.04.014

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (12)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-26 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-03 Medsci0421

    目前达格列净将在国内上市,但有明确心血管获益的是恩格列净

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-03 1e21e196m68(暂无匿称)

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-01 阿吴

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-01 176****9265

    长知识了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-01 lixh1719

    第7条写错了。liraglutide是GLP-1受体激动剂

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1853641, encodeId=ca881853641b4, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 26 16:24:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206073, encodeId=64c22060e36e, content=目前达格列净将在国内上市,但有明确心血管获益的是恩格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Ne59unJiaEKVBVsw2H5iaLnmLt108lIrJ6YTqVphNiao7iaUJuuRE3xickhLErmQ99C3vF1zsf7DKXibuAQLOMjy7cgqj/0, createdBy=a8102049538, createdName=Medsci0421, createdTime=Sat Jun 03 18:21:18 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205904, encodeId=283420590474, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSXS9bNTIRqRqvT3DhruJOjwLhd8vR90odbxNWzgGoGUbhsZ3icBE2VfA7gyQGRW4bILJlKBgCCDl/0, createdBy=109f2024581, createdName=1e21e196m68(暂无匿称), createdTime=Sat Jun 03 08:38:16 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270854, encodeId=0b3612e085463, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325380, encodeId=47a113253808c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390257, encodeId=9374139025e41, content=<a href='/topic/show?id=355398180af' target=_blank style='color:#2F92EE;'>#降糖药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98180, encryptionId=355398180af, topicName=降糖药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 03 03:24:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205309, encodeId=9f51205309b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGx0Nj1tUEG8bCiclXBNCCfjGSeFLCtppUMLTdyCtkvyjxxXViaDnQv43w5VAuic6FGPuCicSgnNKBc3/0, createdBy=21f41994764, createdName=阿吴, createdTime=Thu Jun 01 18:41:29 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205302, encodeId=87e9205302ad, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKmBmKp701U36eJdr3ce0u5SggZ7BUKvXicI6GTwL7eTA1WOnc6zeNxMUYr0S6hAuhqZR7rbct0pwQ/0, createdBy=08de2068775, createdName=176****9265, createdTime=Thu Jun 01 17:40:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205300, encodeId=5db420530042, content=第7条写错了。liraglutide是GLP-1受体激动剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Jun 01 17:31:18 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205248, encodeId=623120524885, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 01 13:42:15 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-01 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

相关资讯

Nature:新型降糖药物问世

葡萄糖激酶(GK)参与葡萄糖平衡的调控,是针对糖尿病的药物发现的一个重要目标,但一些当前的GK活化剂与临床上的低血糖风险增加有关。 这篇论文提出了另一个干预治疗点,它所关注的是肝脏特定的“GK调控蛋白”(GKRP),后者在细胞核中结合并抑制GK。David Lloyd等人报告了一个小分子,即AMG-1694,它专门破坏GK–GKRP复合物,降低高血糖啮齿类模型动物的血糖水平。 重要的是,AMG

美国妊娠期糖尿病新指南仍力挺两步筛查法

近期,美国妇产科医师学会(ACOG)更新妊娠期糖尿病(GDM)治疗指南,仍建议用两步法来诊断GDM。(Obstet Gynecol.2013,122:406) GDM两步诊断法是指:妊娠24~28周先做50g葡萄糖负荷试验进行初步筛查,即口服50g葡萄糖,1h后抽血化验血糖,血糖水平≥7.8mmol/L为异常;异常者需进一步行100g糖耐量试验(OGTT)进行确诊,分别测定空腹血糖(FBG)及负

郭艺芳:降糖与心血管病预防

对于2型糖尿病患者,通过降糖能够预防心血管并发症吗?不知道。尽管UGDP与UKPDS研究结束以来我们经历了一系列坎坷,但理论上讲这种可能性依然存在,关键是用何种方式降糖。众所周知,虽然1型糖尿病与2型糖尿病均以高血糖为主要变现,但二者病理生理机制有很大差异。2型糖尿病的主要机制是胰岛素抵抗,而非胰岛素缺乏。2型糖尿病患者心血管病风险增高的机制是什么?目前仍未最后阐明。基于现有研究结果,桥接2型糖尿

LANCET 子刊:降糖药物可能会提高心脏病风险

有一些降糖类药物或者治疗方法会对心血管产生不利的影响,可能会引发不良心血管事件。2015年3月17日,the Lancet Diabetes&Endocrinology杂志在线发表了一篇论文,作者利用meta分析的方式评估了多种降糖药物或治疗策略是否会提高2型糖尿病患者或高危人群心力衰竭的风险以及风险的程度,并且判断该风险是否与血糖过多或者体重控制相关。 作者在Ovid Medline、

郭艺芳:LEADER研究结果揭晓

2016年第76届ADA年会正在进行中,LEADER研究(Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results - A Long Term Evaluation)结果的揭晓被视为本届会议最大的看点。据刚公布的结果显示,与安慰剂组相比,在常规治疗基础上加用GLP-1类似物利拉鲁肽

CSE 2014:二甲双胍临床应用中国专家共识发表

二甲双胍自1957年问世,应用于临床已有50多年的历史,是当前全球应用最广泛的口服降糖药之一。近年来,虽然有多个新型降糖药物上市,但二甲双胍仍是在全球使用量迅速增加的经典口服降糖药物。二甲双胍具有良好的单药/联合治疗的疗效和安全性证据,以及良好的卫生经济学效益证据。无论对于血糖控制,还是糖尿病心血管并发症的预防,二甲双胍都有明确的临床证据。因此,二甲双胍已经成为全球控制糖尿病的核心药物。然而,在临

Baidu
map
Baidu
map
Baidu
map