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胃病胃癌为什么会“传染”?我国幽门螺旋杆菌感染率已达59%

2017-08-06 佚名 检验医学网

根据今年国际胃癌大会的报告,我国每年新增胃癌病例68万例,占全球发病总数的一半左右。 其中,最小的发病人群已低至25岁,40岁之后的胃癌发病率将增加1倍,其中男性发病率增长尤为显着。

传染了一半中国人的病菌

根据今年国际胃癌大会的报告,我国每年新增胃癌病例68万例,占全球发病总数的一半左右。

其中,最小的发病人群已低至25岁,40岁之后的胃癌发病率将增加1倍,其中男性发病率增长尤为显着。


为什么中国人更容易得胃癌?

其实早在1984年,两名澳大利亚科学家就发现:

胃部感染了幽门螺旋杆菌,是引起胃炎、胃溃疡、胃癌等胃病的最主要原因,并因此获得了诺贝尔医学奖。

如今,幽门螺旋杆菌已被世界卫生组织列为一级致癌物。不仅致癌,几乎100%的慢性胃炎、67%-80%的胃溃疡和95%的十二指肠溃疡也是由这种病菌引起的。

幽门螺旋杆菌可以通过水源、食物传染,中国人吃饭不分餐,互相夹菜,通常家里有一个人感染,几乎全家都会被传染。这也是为什么有家族胃病史的人,要格外注意幽门螺旋杆菌。

据调查,我国幽门螺旋杆菌感染率高达59%,几乎每2个人中就有1人感染。


各地区的幽门螺旋杆菌感染率

不早筛,发现就是晚期

伴随着胃癌发病率的增长,我国胃癌的死亡率也居高不下。

“如果在胃癌发病前就筛查发现幽门螺旋杆菌,治愈率可以达到90%以上。但目前中国住院病例里,九成以上都是胃癌晚期才就医,五年生存率连20%都不到。”

刘主任向我们着重强调了早期筛查的重要性:由于筛查不及时,一发现就是晚期,我国的胃癌五年生存率不到普及早筛国家的1/3。


感染幽门螺旋杆菌的人中,80%以上没有任何症状,幽门螺旋杆最长可在胃中潜伏数十年。很多人有家族胃病史,甚至已经有了胃部不适的症状,仍然没有及时筛查。

其实,提前做一次幽门螺旋杆菌筛查,不仅可以大大降低胃癌风险,也避免了将高危型病菌的再次传染。

而如果发展到胃癌甚至晚期再治疗,不仅要承担高昂的治疗费用,可能还会将高危型病菌传染给家人。

医生建议:

以下4种情况满足任1种,建议尽早做一次预防性筛查:

1. 年龄在30岁以上,从未做过早期筛查

2. 有经常胃痛、胃胀、反酸恶心、打嗝、呕吐反胃、黑色粪便等症状

3. 家族有胃病或胃癌史

4. 本人有胃炎、胃溃疡、十二指肠溃疡等胃病史

科学治疗,避免过度使用抗生素

目前,根除幽门螺旋杆菌主要是以抗生素为主的三联疗法。但过多使用抗生素,不仅对身体会有一定的副反应,也会让病菌产生耐药性。

一人感染,家里的孩子老人很有可能也感染了,全家都吃抗生素治疗并不现实。

其实,幽门螺旋杆菌也分为两种:低危型和高危型。

高危型菌种极易导致细胞异常,导致胃/十二指肠溃疡、淋巴瘤的几率大大增加,胃癌发病率是低危型的20倍以上。


不同疾病感染高危型菌种的比例

感染低危型菌种,如果身体没有很明显的症状,可以考虑改善饮食习惯,暂时不杀菌,避免抗生素过度治疗。

但如果感染的是高危型,需要立即接受杀菌治疗,并让家人也进行筛查。治疗期间与家人的食物、餐具、饮水等都要分开,今后的饮食习惯也要格外得注意。

常见的早期筛查方法有:

1.创伤性侵入性检查:胃镜

胃镜利用一根直径约一公分的黑导光纤维管子,由患者的嘴中伸入观察并取样。检查时因空气随管子进入胃中,胃镜碰到食道、胃壁或进入较深,可能引起胀气、恶心和疼痛感。

做胃镜侵入性强,不少人因为抵触胃镜一直不愿意做筛查。同时,胃镜下做幽门螺杆菌检测有一定漏检概率,例如取材部位刚好没有幽门螺杆菌,造成假阴性。

2.C-14尿素呼气检测

C-14尿素呼气检测是常见的幽门螺旋杆菌检测方法。但因为吞服胶囊中含有放射性物质,孕妇、哺乳期和儿童不建议做C-14尿素呼气检测。

此外,C-14尿素呼气检测只能判断是否感染,无法区分高危型和低危型,大多数的感染患者可能都需要使用抗生素杀菌治疗,可能造成抗生素的过度治疗。

3.粪便无创分型检测

在《第四次全国幽门螺杆菌感染处理共识报告》中,粪便分型检测被列为七种检测方法之一,并在临床中使用。相比常规的C-14呼气检测,粪便无创分型检测的灵敏度为93.1%,特异性达到96.8%,完全达到精确检测的要求。

通过提取肠道脱落细胞DNA和胃肠道菌群DNA,粪便无创分型检测不仅可以检测是否感染,还可以区分高危型和低危型菌种,针对不同菌种有效降低胃病和胃癌的发病几率,避免过度使用抗生素治疗。

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    2017-10-20 jyzxjiangqin

    胃癌的发病机制.

    0

  3. 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GetPortalCommentsPageByObjectIdResponse(id=231431, encodeId=abc82314316a, content=幽门螺杆菌有没有彻底治疗的药物吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Aug 08 10:29:36 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532486, encodeId=6b59153248600, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Mon Aug 07 23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-10-07 jyzxjiangqin

    胃癌的治疗.

    0

  4. 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time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232436, encodeId=63b0232436a0, content=胃病胃癌的传染。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 11 10:09:13 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231960, encodeId=3d8423196077, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Aug 09 21:57:36 CST 2017, time=2017-08-09, status=1, ipAttribution=), 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-09-22 jyzxjiangqin

    HP感染率已达59%.

    0

  5. 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-09-08 jyzxjiangqin

    胃癌的治疗.

    0

  6. 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-24 jyzxjiangqin

    胃病胃癌的治疗.

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=231431, encodeId=abc82314316a, content=幽门螺杆菌有没有彻底治疗的药物吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Aug 08 10:29:36 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532486, encodeId=6b59153248600, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Mon Aug 07 23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-11 jyzxjiangqin

    胃病胃癌的传染。

    0

  8. 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time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232436, encodeId=63b0232436a0, content=胃病胃癌的传染。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 11 10:09:13 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231960, encodeId=3d8423196077, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Aug 09 21:57:36 CST 2017, time=2017-08-09, status=1, ipAttribution=), 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-09 thlabcde

    好东西学习了!

    0

  9. 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time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232436, encodeId=63b0232436a0, content=胃病胃癌的传染。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 11 10:09:13 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231960, encodeId=3d8423196077, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Aug 09 21:57:36 CST 2017, time=2017-08-09, status=1, ipAttribution=), 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-08 flysky120

    幽门螺杆菌有没有彻底治疗的药物吗?

    0

  10. 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time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232436, encodeId=63b0232436a0, content=胃病胃癌的传染。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Aug 11 10:09:13 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231960, encodeId=3d8423196077, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Aug 09 21:57:36 CST 2017, time=2017-08-09, status=1, ipAttribution=), 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23:30:00 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-07 xiaoshitou

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