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CELL HOST MICROBE:微生物竞争营养物质,影响宿主代谢发育

2017-08-27 海北 MedSci原创

胆碱是生物体必须的营养物质,也是表观调节的甲基供体。其可以维护细胞膜结构的完整性,支持胆碱能神经传递。长期饮食缺乏胆碱会导致表观遗传调控的严重改变。DNA甲基化的变化和多种人类疾病相关,包括癌症,衰老,动脉粥样硬化,认知障碍(如抑郁症,焦虑症,精神分裂症或阿尔茨海默病),和自身免疫性疾病。此外,胆碱在脂质代谢中也起了重要作用。虽然胆碱在日常饮食中丰度很高,但医学研究所估计,只有约10%的美国人口一

胆碱是生物体必须的营养物质,也是表观调节的甲基供体。其可以维护细胞膜结构的完整性,支持胆碱能神经传递。长期饮食缺乏胆碱会导致表观遗传调控的严重改变。DNA甲基化的变化和多种人类疾病相关,包括癌症,衰老,动脉粥样硬化,认知障碍(如抑郁症,焦虑症,精神分裂症或阿尔茨海默病),和自身免疫性疾病。此外,胆碱在脂质代谢中也起了重要作用。虽然胆碱在日常饮食中丰度很高,但医学研究所估计,只有约10%的美国人口一直达到或超过每日推荐摄入量。

来自威斯康星大学的研究人员利用缺乏单一胆碱利用酶的微生物群落,评估肠道微生物的胆碱代谢对细菌适应性和宿主生物学的影响。

研究结果表明,胆碱利用细菌会和宿主竞争这种营养,显著影响血浆和肝脏中甲基供体代谢物的水平,并表现出缺乏胆碱的生化特征。含有高水平胆碱消耗细菌的小鼠在高脂肪饮食下,表现出对代谢疾病易感性的增加。此外,细菌引起的可利用甲基供体降低会影响了成年小鼠及其后代的DNA甲基化模式,并引起行为的改变。

因此,研究人员的结果揭示了细菌胆碱代谢对宿主代谢,表观遗传学和行为的不良影响。进而,我们在制定最佳营养摄入量时,应考虑微生物代谢的人际差异。


原始出处:

Kymberleigh A. Romano et al.  Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline ConsumptionCell Host & Microbe, 2017 DOI: 10.1016/j.chom.2017.07.02


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    2017-10-21 维他命
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    2017-12-10 xjy02
  4. 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  5. 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  6. 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encodeId=2b5623e71957, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 27 13:37:37 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237704, encodeId=033f23e70410, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 27 12:44:44 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237680, encodeId=7c1f23e680c2, content=非常好的文章.学习了.很受益非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Aug 27 11:31:20 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-28 wincls
  7. 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topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Jun 07 06:38:00 CST 2018, time=2018-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870144, encodeId=1b2d18e0144dd, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Feb 27 06:38:00 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404684, encodeId=bbf214046845f, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, 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encodeId=2b5623e71957, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 27 13:37:37 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237704, encodeId=033f23e70410, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 27 12:44:44 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237680, encodeId=7c1f23e680c2, content=非常好的文章.学习了.很受益非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Aug 27 11:31:20 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-28 neurowu
  8. [GetPortalCommentsPageByObjectIdResponse(id=1824818, encodeId=f98e182481851, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Mar 15 05:38:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960405, encodeId=01041960405ab, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, 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encodeId=2b5623e71957, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 27 13:37:37 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237704, encodeId=033f23e70410, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 27 12:44:44 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237680, encodeId=7c1f23e680c2, content=非常好的文章.学习了.很受益非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Aug 27 11:31:20 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-27 131****1460

    学习了受益匪浅.

    0

  9. 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encodeId=2b5623e71957, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 27 13:37:37 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237704, encodeId=033f23e70410, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 27 12:44:44 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237680, encodeId=7c1f23e680c2, content=非常好的文章.学习了.很受益非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Aug 27 11:31:20 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-27 清风拂面

    学习受益匪浅.谢谢分享

    0

  10. 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encodeId=2b5623e71957, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 27 13:37:37 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237704, encodeId=033f23e70410, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 27 12:44:44 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237680, encodeId=7c1f23e680c2, content=非常好的文章.学习了.很受益非常好的文章.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Aug 27 11:31:20 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-27 天涯183

    非常好的文章.学习了.很受益非常好的文章.学习了.很受益

    0

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已有的大量报道显示,肠道微生物群对于宿主的生理影响体现在多个方面,包括发育,生殖,免疫,营养和寿命。此外,微生物还和宿主的健康行为相关,比如交配和社会行为。尽管肠道微生物菌群对于宿主的健康起着至关重要的作用,但是现有的研究还不能解释,为什么宿主会和环境中特定的一群微生物联系在一起。

Nat Commun:微生物所揭示结核分枝杆菌与宿主相互作用的分子机制

由结核分枝杆菌(Mycobacterium tuberculosis, Mtb)引起的结核病是一种古老的慢性传染病,并且至今仍是全球死亡人数最多的单一传染病。据世界卫生组织(WHO)报道:2015年全球有1040万新发结核病患者,有180万人死于结核病。

Sci Rep:新型DNA微阵列可迅速检测口腔微生物群

口腔微生物的定量表征对于彻底了解牙周病理过程中口腔生态以及牙周微生物组成改变来说是至关重要的。在这项研究中,研究人员设计并验证了一个新的DNA微阵列(OralArray),以迅速并可靠地检测定植于口腔中最有代表性的细菌。OralArray是基于与通用阵列(LDR-UA)相关的连接检测反应技术,包括靶向厚壁菌门,放线菌,拟杆菌、变形菌、梭杆菌细菌和螺旋体的22个探针组。该仪器具有特异性强、灵敏度高、

Science:植物类黄酮“联手”肠道微生物抵御流感病毒,中草药抗流感也许找到科学依据了!

今天,华盛顿大学医学院的研究人员在《科学》杂志发表了一项重磅研究,他们发现广泛存在于天然植物中的黄酮类化合物,经过肠道微生物的降解,产生的代谢物被吸收后,能够上调I型干扰素信号通路,进而增强机体抗病毒免疫反应!

Cell:肠癌大突破!上海交大科学家发现了肠道微生物导致化疗耐药的机制

近日,来自上海交通大学医学院附属仁济医院消化科的房静远教授、陈萦晅副教授、洪洁和陈豪燕副研究员以及美国密西根大学邹伟平教授合作,首次从作用机制上证明具核梭杆菌(Fusobacterium nucleatum)可以通过调节癌细胞的自噬作用,促进结直肠癌对化疗的耐受。而具核梭杆菌恰恰是我们口腔中常见的革兰氏阴性菌。这一重要发现发表在顶级期刊《细胞》杂志上。

PNAS:细菌产生的吲哚可以延长健康寿命

已有的多个研究表明,在不同的生物体中,有保守的遗传途径以及小分子能够延长机体寿命。但是,寿命的延长并不意味着健康寿命的延长。健康寿命指的是动物保持健康,没有发生与年龄相关的疾病的时间。相反,现有的延长寿命的突变往往伴随着健康寿命的减少,以及机体的虚弱。因此,一直以来人们都在好奇,是否存在这样的因素或机制,能够独立于机体寿命,延长健康寿命,减少机体的虚弱。

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