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Thorax:囊性纤维化对出生体重的影响

2018-07-21 xing.T MedSci原创

由此可见,CF显著影响宫内生长,并导致CF患儿出生体重降低,这只是妊娠期缩短的部分原因。

婴儿期和儿童期不良生长是囊性纤维化(CF)的一个特征。然而,CF对宫内生长的影响尚不清楚。近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员探究了CF对出生体重的影响,并评估了任何关联是否是出生时胎龄差异所致。

研究人员使用来自于丹麦(1980-2010年)和威尔士(1998-2015年)出生的220万单胎受试者的数据,在这两个国家进行了国家登记联系研究。同时,使用医院住院和门诊数据来识别852名患有CF的儿童。经因果调解方法,研究人员估计了调整了性别、产次和社会经济背景后CF对出生体重的直接和间接(通过孕龄)影响,并通过调整其他因素来评估结果的稳健性,例如在有这些数据中妊娠期间母亲吸烟的亚人群。

患有CF的婴儿早产和出生体重低的婴儿比没有CF的婴儿更高(丹麦和威尔士早产分别为12.7%vs. 5%和9.4%vs. 5.8%; 低出生体重分别为11.9% vs. 4.2%和11% vs. 5.4%)。使用因果调解方法,CF对出生体重的总体影响估计在丹麦人群中为-178.8g(95%CI为-225.43至-134.47g),以及在在威尔士人群中为-210.08g(95%CI为-281.97至-141.5 g)。CF对出生体重的这种影响约40%是通过孕龄介导的。

由此可见,CF显著影响宫内生长,并导致CF患儿出生体重降低,这只是妊娠期缩短的部分原因。

原始出处:

Daniela K Schlüter, et al. Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales.Thorax. 2017. http://dx.doi.org/10.1136/thoraxjnl-2018-211706

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    2018-08-22 wolongzxh
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    2018-07-21 医者仁心5538

    学习了

    0

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    2018-07-21 zb1235672

    学习了!!!!!

    0

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