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PLos One:体脂分布对药物洗脱支架植入后长期临床预后的影响

2018-05-29 xiangting MedSci原创

在DES治疗的患者中,躯干脂肪分布与临床预后不良相关,并比BMI更具临床相关性。

体脂分布与心血管病和预后密切相关,但体脂分布对药物洗脱支架(DES)经皮冠脉介入治疗(PCI)后患者预后的影响尚未得到评估。这项研究调查了躯干脂肪分布对DES后长期临床结局的影响。441名接受DES治疗的患者,PCI后进行双能X线吸收测定以评估总体和局部的体脂分布。计算躯干脂肪与总脂肪质量的比值(%FM躯干/FM总体)作为躯干脂肪分布的代表性参数。主要终点是主要不良心脏事件(MACE),以及5年时缺血驱动的靶血管血运重建(TVR)、非手术心肌梗死和心源性死亡的复合。在1780天的中位随访期内,22.0%的患者出现MACE,FM躯干/FM总数的最高四分位组比最低四分位组MACE的发生率高(27.8%vs.15.3%; log rank p=0.026)。这种差异是由缺血驱动的TVR发生率较高所致(25.9%vs.9.9%; log rank p = 0.008)。在多因素Cox回归分析中,%FM躯干/FM 总数与MACE独立相关(危险比:1.075; 95%CI:1.022-1.131; p = 0.005),但体重指数(BMI)不与MACE独立相关。在DES治疗的患者中,躯干脂肪分布与

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    2018-05-31 jiyangfei
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1790213, encodeId=5f2c1e90213c6, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Mar 08 09:09:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998759, encodeId=d8d11998e592b, content=<a href='/topic/show?id=80936510423' target=_blank style='color:#2F92EE;'>#洗脱支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65104, encryptionId=80936510423, topicName=洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e72268, createdName=zhixianchen, createdTime=Sun Sep 30 09:09:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935160, encodeId=611d193516016, content=<a href='/topic/show?id=49455e1086e' target=_blank style='color:#2F92EE;'>#支架植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57108, encryptionId=49455e1086e, topicName=支架植入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Mar 22 14:09:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310489, encodeId=0ec5131048958, content=<a href='/topic/show?id=f70e8e78941' target=_blank style='color:#2F92EE;'>#药物洗脱支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87789, encryptionId=f70e8e78941, topicName=药物洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu May 31 06:09:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520484, encodeId=44e515204844b, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu May 31 06:09:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534723, encodeId=cb151534e23a1, content=<a href='/topic/show?id=6be9230842e' target=_blank style='color:#2F92EE;'>#临床预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23084, encryptionId=6be9230842e, topicName=临床预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72412536387, createdName=budeshao, createdTime=Thu May 31 06:09:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544068, encodeId=4f9015440687b, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Thu May 31 06:09:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319895, encodeId=897331989595, content=好文献.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Wed May 30 07:27:44 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319695, encodeId=7a5a31969505, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue May 29 15:37:36 CST 2018, time=2018-05-29, status=1, ipAttribution=)]
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    2018-05-30 张新亮1853311252142e2fm

    好文献.学习了

    0

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    2018-05-29 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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一波三折!患者PCI术后40天再现心包压塞

67岁男性患者因“胸闷5小时”入院,给予常规治疗未见好转,遂行冠状动脉造影及支架手术。术后患者胸闷症状缓解,然而,术后反复出现起搏功能不良,超声提示大量心包积液,考虑临时起搏电极穿孔导致急性心包压塞,行心包引流,术后一周出院。术后40天患者再次出现心包积液。为何PCI术后会出现心包压塞?该患者再次出现的原因又是什么?详见以下病例——

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