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Radiology：钆增强MR扫描后钆剂会出现在脑脊液中！

2018-07-18 shaosai MedSci原创

钆剂MR脑脊液
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本研究旨在评价是否在钆剂对比剂（GBCA）增强MR成像（MRI）后会渗透到脑脊液（CSF）中，并将结果发表在Radiology上。

本研究旨在评价是否在钆剂对比剂（GBCA）增强MR成像（MRI）后会渗透到脑脊液（CSF）中，并将结果发表在Radiology上。

本研究共分析了来自57例行钆特酸葡胺对比剂增强MRI检查且在之后60天内进行CSF取样患者（中位数年龄为50岁，范围3-92岁）的60份标本。分析行MRI平扫的患者（n = 22）或在行CSF抽样1年内行增强MRI检查的患者（n = 2）的CSF标本并作为对照。利用钆158同位素电感耦合等离子体质谱法侧列CSF指标。利用Kruskal-Wallis检验进行统计学分析。

结果为，在行GBCA增强8小时内的患者CSF中钆剂浓度要明显增高（平均浓度为1152 ng/mL ± 734.6）。在8-48小时候浓度降低。在48小时候，CSF中的钆剂几乎被完全清除(121 ng/mL ± 296.3)。其中有2/24例对照者中CSF标本为阴性。而对于行GBCA增强MRI检查超过1年后行CSF检查的患者浓度减低（1或3年后分别为0.1 and 0.2 ng/mL）。在慢性肾衰竭、脑弓形虫病和肝硬化的患者CSF中钆剂浓度要高。

本研究表明，钆特酸葡胺在静脉注射后可在人类CSF中检出。

原始出处：

Berger F， Kubik-Huch RA， Niemann T. et al.Gadolinium Distribution in Cerebrospinal Fluid after Administration of a Gadolinium-based MR Contrast Agent in Humans.Radiology.DOI：10.1148/radiol.2018171829

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    2018-09-30 ms1692810954239974

    #钆剂#

    0

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    2018-07-18 lyh994

    时间这么久啊

    0

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    2018-07-18 zb1235672

    学习了

    0

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    2018-07-18 liumin1987

    学习学习涨见识了

    0

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    2018-07-18 1209e435m98(暂无昵称)

    学习了谢谢分享

    0

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    2018-07-18 神功盖世

    阅

    0

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    2018-07-18 哈哈869

    学了

    0

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    2018-07-18 哈哈869

    学了

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    2018-07-18 yjs木玉

    好好好好好好好好

    0

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