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JCO:普瑞巴林治疗头颈部肿瘤患者放疗相关神经性疼痛

2018-11-29 MedSci MedSci原创

头颈肿瘤患者接受放疗过程中出现神经性疼痛是不可避免。JCO近期发表了一篇文章,研究普瑞巴林治疗放疗相关神经性疼痛的疗效和安全性。

头颈肿瘤患者接受放疗过程中出现神经性疼痛是不可避免。JCO近期发表了一篇文章,研究普瑞巴林治疗放疗相关神经性疼痛的疗效和安全性。

该试验在中国的四个中心进行。适合入组的患者随机分入接受使用普瑞巴林治疗16周组或安慰剂组。主要疗效结果是评定量表评估的疼痛减轻情况。研究最终纳入128名患者。在第16周时,普瑞巴林组疼痛强度降低程度2.44,安慰剂组为1.58,平均差异为0.87。在普瑞巴林组中,38名患者(59.4%)实现了至少30%的疼痛缓解,而安慰剂组为21名(32.8%)(P = .006)。普瑞巴林组19例(29.7%),安慰剂组5例(7.8%)疼痛缓解率达50%或更高(P= .003)。与安慰剂组相比,接受普瑞巴林治疗组的患者心境状况总分,疼痛严重程度,功能干扰情况以及生活质量均在第16周时显着改善。普瑞巴林组与安慰剂组相比,不良事件的发生率无显着差异(P = .29)。

文章最后认为,与安慰剂组患者相比,接受普瑞巴林治疗的放疗相关神经性疼痛患者疼痛缓解程度更高,情绪状态更好,生活质量更高,耐受性良好。

原始出处:

Hideaki Takahashi, Yuichiro Tada, et al. Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Salivary Duct Carcinoma. JCO. November 2018 doi: 10.1200/JCO.18.00545

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    2019-07-07 lidong40
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    2018-12-01 wshxjq
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    2018-11-29 天地飞扬

    了解一下,谢谢分享!

    0

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