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Hepatology:咖啡和茶可能减少非酒精性脂肪肝(NAFLD)患者脂肪肝发生率

2013-08-23 MedSci MedSci原创

Duke-NUS大学医学研究生院和杜克大学医学院的研究者们表示,增加咖啡的摄入量或可减少非酒精性脂肪肝(NAFLD)患者的脂肪肝发生率。 NAFLD是除了过量饮酒以外,导致脂肪肝的主要原因。在全世界的糖尿病合并肥胖的人群中,70%患有NAFLD。据估算,美国约有30%的人口患有此疾病,且该病在新加坡的患病率一直处于上升趋势。除饮食和运动干预外,NAFLD的治疗尚无有效方法。 通过细胞培

Paul Yen, M.D., is an associate professor and research fellow, Duke-NUS Graduate Medical School.

Duke-NUS大学医学研究生院和杜克大学医学院的研究者们表示,增加咖啡的摄入量或可减少非酒精性脂肪肝(NAFLD)患者的脂肪肝发生率。

NAFLD是除了过量饮酒以外,导致脂肪肝的主要原因。在全世界的糖尿病合并肥胖的人群中,70%患有NAFLD。据估算,美国约有30%的人口患有此疾病,且该病在新加坡的患病率一直处于上升趋势。除饮食和运动干预外,NAFLD的治疗尚无有效方法。

通过细胞培养和小鼠模型,研究者Paul Yen 博士和Rohit Sinha博士等观察到,咖啡因对肝脏细胞中脂肪的代谢有促进作用,并可减少高脂饲喂小鼠的脂肪肝发生率。这些发现表明,一天摄入4杯咖啡或茶当量的咖啡因可能对避免人类NAFLD发生和发展有益。

相关研究结果将发表于九月份的Hepatology杂志。

“这是首个详细研究了咖啡因对肝脏中脂质作用的试验,数据结果非常有趣,”Yen表示。

原始出处:

Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM.Caffeine stimulates hepatic lipid metabolism via autophagy-lysosomal pathway.Hepatology. 2013 Aug 8. doi: 10.1002/hep.26667.

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    2014-04-01 lvygwyt2781
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    2013-08-25 hbwxf
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    2013-08-25 gwc384

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