FDA批准阿斯利康痛风药物Lesinurad治疗痛风相关高尿酸血症

2015-12-23 MedSci MedSci原创

FDA批准阿斯利康痛风药物 Lesinurad(Zurampic) （200mg/d）与黄嘌呤氧化酶抑制剂 (XOI)一起用于治疗痛风相关高尿酸血症。Lesinurad 可尿酸的排泄，减少其生成。控制高尿酸血症是痛风长期治疗的重中之重，Zurampic为数百万一生中可能出现痛风的人群提供了一种新的治疗选择。痛风表现为突然发生的关节剧烈疼痛和肿胀，最常见于大脚趾。在美国有160万名痛风患者，其中85

FDA批准阿斯利康痛风药物 Lesinurad(Zurampic) （200mg/d）与黄嘌呤氧化酶抑制剂 (XOI)一起用于治疗痛风相关高尿酸血症。Lesinurad 可尿酸的排泄，减少其生成。

控制高尿酸血症是痛风长期治疗的重中之重，Zurampic为数百万一生中可能出现痛风的人群提供了一种新的治疗选择。

痛风表现为突然发生的关节剧烈疼痛和肿胀，最常见于大脚趾。在美国有160万名痛风患者，其中85%为男性。高尿酸血症患者中只有一部分会发展为痛风。

三项随机安慰剂对照试验评估了lesinurad+XOI的安全性和有效性，涉及1537名参与者，试验长达12个月。试验结果显示药物治疗组与对照组相比，血尿酸水平下降。不良反应包括头痛、血肌酐增加、胃食管返流疾病等。如果不联合XOI或使用较大剂量lesinurad会增加急性肾功衰风险。

FDA顾问委员在10月份建议批准该药物上市,但一些成员对药物的安全性表示担忧。与安慰剂相比，400mg的lesinurad剂量会导致不良事件、严重不良事件、肾功能不良事件、主要心血管不良事件和死亡风险增加。

最后批准200mg的药物剂量，该剂量下严重不良事件发生率较低，被认为是安全的。

原始出处：

FDA Approves Zurampic for Patients With Gout

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#插入话题

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2016-01-13 liye789132251

#lesinurad#

99 0
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2016-07-19 bugit

#FDA批准#

64 0
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2015-12-26 忠诚向上

好学习

168 0
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2015-12-25 ms622625817193301

#高尿酸#

72 0
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2015-12-25 skhzy

#ESI#

71 0
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2015-12-24 zhuzhuba1

牛

236 0
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2015-12-24 nizongzan

赞一个

179 0
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2015-12-24 nizongzan

现在痛风的几率很高

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