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Ann Intern Med:韩国30万国家队列研究:妊娠早期服用抗甲状腺药物祸及子女

2018-01-24 MedSci MedSci原创

韩国学者在Ann Intern Med发表研究称,患有Graves病的女性在妊娠头三个月服用抗甲状腺药物甲巯咪唑和丙硫氧嘧啶显着增加新生儿先天畸形风险。

韩国学者在Ann Intern Med发表研究称,患有Graves病的女性在妊娠头三个月服用抗甲状腺药物甲巯咪唑和丙硫氧嘧啶显着增加新生儿先天畸形风险。

研究人员分析了近30万例成功分娩妊娠女性,有12891例(0.45%)在妊娠头三个月内服用过抗甲状腺药物。

数据显示,妊娠头三个月服用抗甲状腺药物的女性分娩出的新生儿中,有937例(7.27%)患先天性畸形,而没有服用抗甲状腺药物的女性分娩出的新生儿中,有170716例(5.94%)先天性畸形。

进一步分析,总体上讲,妊娠头三个月服用抗甲状腺药物使新生儿先天性畸形分析增加24%。

服用甲巯咪唑和丙硫氧嘧啶分别使新生儿畸形相对风险增加31%和6%。

先天性畸形发生率的绝对风险分析显示,与未服用抗甲状腺药物相比,服用丙硫氧嘧啶,则每1000例活产儿中有8.81例会出现先天性畸形,服用甲巯咪唑,则每1000例活产儿中有17.05例会出现先天性畸形,服用两种药物甲巯咪唑和丙硫氧嘧啶时,每1000例活产儿中有16.53例会出现先天性畸形。

原始出处:
Seo GH, Kim TH, Chung JH.Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study.Ann Intern Med. 2018 Jan 23. doi: 10.7326/M17-1398. [Epub ahead of print]

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    2018-01-24 清风拂面

    谢谢分享.学习受益匪浅

    0

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    2018-01-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

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    2018-01-24 戒馋,懒,贪

    谢谢分享学习了

    0

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