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AAOS 2016:ADHD治疗药物会导致患儿骨骼发育不良

2016-03-04 MedSci MedSci原创

2016年美国矫形外科医师学会年会(AAOS)上,美国陆军外科研究所的Jessica Rivera博士提出ADHD治疗药物会导致患儿骨骼发育不良。 CDC指出,2011年美国约有640万名儿童被诊断出患有注意缺陷多动障碍(ADHD)。 ADHD儿童易出现注意力不集中、白日梦、健忘、坐立不安、说话尖酸刻薄、粗心、难以与他人相处。尽管研究人员目前正在研究ADHD的成因和风险因素,研究表明基因起到了重要

2016年美国矫形外科医师学会年会(AAOS)上,美国陆军外科研究所的Jessica Rivera博士提出ADHD治疗药物会导致患儿骨骼发育不良。

CDC指出,2011年美国约有640万名儿童被诊断出患有注意缺陷多动障碍(ADHD)。

ADHD儿童易出现注意力不集中、白日梦、健忘、坐立不安、说话尖酸刻薄、粗心、难以与他人相处。尽管研究人员目前正在研究ADHD的成因和风险因素,研究表明基因起到了重要的作用,但很多因素仍然未知。其他可能的原因和危险因素包括脑损伤、环境因素(如铅)、孕妇吸烟和饮酒、早产、婴儿低出生体重等因素。

CDC指出,当前研究并不支持ADHD与摄入糖太多、看电视、社会经济因素等有关。研究人员指出,相比2011年,2007年患ADHD的儿童和青少年多了350万名,增加了28%。

为了进一步调查这些药物对儿童骨骼健康的影响,研究人员评估了NHANES研究中的5315名儿童,并比较服用ADHD药物和不服用ADHD药物的孩子的健康状况。

患儿常用的药物多为:哌醋甲酯(利他林)、右哌甲酯、右旋安非他命、 阿托莫西汀和二甲磺酸赖右苯丙胺。

结果表明,服用ADHD药物治疗的儿童股骨、股骨颈、腰椎骨矿物质密度较不服用药物的孩子低。

约25%服用药物的儿童骨量减少,即骨密度峰值降低。虽然在儿童服用ADHD药物与骨质疏松、骨质缺乏之间的联系对儿童以后生活的影响还没有得到证实,但研究人员认为儿童骨密度降低对儿童有长期不利影响。

服用治疗ADHD的药物会导致儿童出现肠胃问题,包括食欲下降和肠胃不适,研究人员认为这与儿童营养不足和钙摄入量减少有关。此外,药物有可能改变儿童交感神经系统的发育。Rivera博士指出,医生应谨慎考虑ADHD患儿是否应服用治疗药物并预防可能出现的各种副作用和不良反应。

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    2018-03-19 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-03-11 1e145228m78(暂无匿称)

    学习了.谢谢作者分析!

    0

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  4. 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  5. 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href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sun Mar 06 11:11:00 CST 2016, time=2016-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67391, encodeId=1b9c6e39134, content=谢谢分享,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat Mar 05 18:11:00 CST 2016, time=2016-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67296, encodeId=6a116e2969d, content=要注意点, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 05 10:21:00 CST 2016, time=2016-03-05, status=1, ipAttribution=)]
    2016-03-23 yinhl1978
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67296, encodeId=6a116e2969d, content=要注意点, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 05 10:21:00 CST 2016, time=2016-03-05, status=1, ipAttribution=)]
    2016-03-06 lg.zhao
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67296, encodeId=6a116e2969d, content=要注意点, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 05 10:21:00 CST 2016, time=2016-03-05, status=1, ipAttribution=)]
    2016-03-06 neurowu
  8. 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  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67296, encodeId=6a116e2969d, content=要注意点, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 05 10:21:00 CST 2016, time=2016-03-05, status=1, ipAttribution=)]
    2016-03-05 I come

    谢谢分享,不错

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=67296, encodeId=6a116e2969d, content=要注意点, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 05 10:21:00 CST 2016, time=2016-03-05, status=1, ipAttribution=)]
    2016-03-05 忠诚向上

    要注意点

    0

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据Cochrane上最新发表的一篇综述表明,用于治疗小儿多动症(ADHD)的药物哌甲酯,可能会导致儿童失眠和食欲不振。

Epidemiology:孕期高水平VD或可降低后代ADHD类似行为发生风险

孕妇体内维生素D含量在胎儿大脑发育期间,可能会影响其后代儿童期注意缺陷多动障碍(ADHD)类似行为发生的风险。但是目前临床上没有关于该问题的前瞻性研究。因此Morales E等人进行了一项调查以探究孕期维生素D含量跟后代儿童期ADHD类似行为发生风险的联系。

J Psychiat Res:ADHD和TBI关系密切

通过对加拿大安大略市的成人进行电话访谈,研究人员发现,ADHD(注意缺陷多动障碍)和TBI(创伤性脑损伤)之间关系明显。Robert Mann认为,患有TBI的成人患ADHD的可能性是未患TBI的成人的2倍多。这项研究发表在the Journal of Psychiatric Research。注意缺陷多动障碍(ADHD)是一种长期的行为障碍,其特点是行为冲动和注意力不集中。这种情况通常出现于儿童

女性幼年期患注意缺陷多动障碍,则成年后肥胖风险大

在过去30年里,儿童和成人肥胖的发病率大幅上升,且有证据表明这与注意缺陷多动障碍(ADHD)明显相关。 既往研究已经表明,由于潜在的行为学、神经生物学和遗传机制等因素,ADHD和肥胖之间密切相关。 ADHD儿童易冲动和注意力不集中等行为因素会导致他们饮食不规律。 遗传和神经生物学因素可导致患儿多巴胺分泌系统或脑源性嗜神经因子(BDNF)分泌出现障碍。 既往研究指出,共同的病因学可能导致ADHD患儿

BMJ研究新闻:值得关注!在过去的十年里美国儿童ADHD的患病率增加了43%

据美国国家调查显示,2011年八分之一的美国儿童和青少年患有注意缺陷多动障碍(ADHD),自2003年以来增长了43%。儿童ADHD的患病率呈上升趋势。5-17岁儿童ADHD的总患病率从2003年的8.4%上升至2011年的12%,增长了43%。在这期间,不同种族之间的儿童ADHD患病率的线性增长趋势类似。但是以西班牙裔的儿童增长率最大(83%)。

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