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JAMA Cardiol:房颤相关的心血管疾病及其死亡率存在种族差异

2016-07-26 phylis 译 MedSci原创

重要性:在白人队列的研究中,心房颤动(AF)与不良后果相关究。房颤相关预后的种族差异仍在持续调查。目的:评价社区人群中,房颤与卒中、心力衰竭,冠心病(CHD)和全因死亡率的种族特异性的相关性。设计、设置和参与者:社区动脉粥样硬化风险(ARIC)研究是一项前瞻性、观察性队列研究。从1987到1989,ARIC研究纳入15 792例男性和女性,进行了4次随访检查(2011-2013)。种族是由自我报告

重要性:在白人队列的研究中,心房颤动(AF)与不良后果相关。房颤相关预后的种族差异仍在持续调查。

目的:评价社区人群中,房颤与卒中、心力衰竭,冠心病(CHD)和全因死亡率的种族特异性的相关性。

设计、设置和参与者:社区动脉粥样硬化风险(ARIC)研究是一项前瞻性、观察性队列研究。从1987到1989,ARIC研究纳入15 792例男性和女性,进行了4次随访检查(2011-2013)。种族是由自我报告,归类为白色、黑色或其他。

主要成果和措施:心房颤动(使用心电图、出院的代码和死亡证明确定)、卒中、心力衰竭、冠心病和死亡率。

结果:排除后,共有15 080名受试者(平均年龄[SD],54.2 [ 5.8 ]岁; 8290[ 55.5% ]为女性;黑人3831例[ 25.4% ])纳入分析。 平均随访(SD)20.6 (6.2)年,共2348例发生房颤,白人每1000人-年房颤的发生率为8.1(95% CI,7.7-8.5),黑人为5.8(95% CI,5.2-6.3)。黑人AF患者脑卒中、心力衰竭、冠心病率和死亡率明显高于白人AF患者。AF和预后相关(差异率估计:每1000人-年房颤患者终点发生率减去非房颤患者终点发生率),也有种族差异。白人房颤患者卒中的差异率为10.2(95% CI,6.6-13.9),黑人的为21.4(95% CI,10.2-32.6)。黑人房颤患者心衰和CHD的差异率是高于白人1.5至2.0倍。白人房颤患者死亡的差异率为55.9(95% CI,48.1-63.7),黑人为106(95% CI,86.0-125.9)。

结论与相关性:在前瞻性的ARIC研究,黑人AF对卒中、心力衰竭、冠心病和死亡率的影响比白人更大。这些结果表明,黑人房颤患者风险增加。对房颤和相关不良预后的种族差异研究持续是很必要的,可用来识别并整合房颤治疗的种族差异。

原始出处:


Magnani JW, Norby FL, et al. Racial Differences in Atrial Fibrillation-Related Cardiovascular Disease and Mortality: The Atherosclerosis Risk in Communities (ARIC) Study.JAMA Cardiol. 2016 Jul 1;1(4):433-41. doi: 10.1001/jamacardio.2016.1025.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1781722, encodeId=c9b61e8172292, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Mon Sep 26 00:11:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145336, encodeId=3bda145336dd, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:14:59 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142870, encodeId=edf31428e0f5, content=谢谢指点迷津, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sun Oct 09 23:46:12 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135083, encodeId=f68c135083ff, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353556, encodeId=71b21353556e6, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jul 27 21:11:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498031, encodeId=a5f61498031d2, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Jul 27 21:11:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

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    2016-10-09 1e0ece0dm09(暂无匿称)

    谢谢指点迷津

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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