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Obstet Gynecol:无高血压或糖尿病的肥胖妇女所生子女新生儿发病率分析

2018-09-11 xing.T MedSci原创

由此可见,在分娩患者中,即使没有高血压疾病或糖尿病,产妇肥胖也是导致新生儿发病增加的独立危险因素。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在比较没有高血压糖尿病的肥胖和非肥胖女性的子女之间新生儿发病率的独立风险。

该研究是对2010年至2014年期间妊娠37周或以上单胎分娩的前瞻性单中心队列研究进行的二次分析。糖尿病(妊娠前或妊娠期)和高血压疾病的女性被排除在外。该研究的主要结局是1)新生儿发病复合事件,包括死亡、机械通气、呼吸窘迫、胎粪吸入、疑似败血症、确诊脓毒症、缺氧缺血性脑病、治疗性低温或癫痫发作; 2)新生儿神经系统疾病复合事件,包括缺氧缺血性脑病、治疗性低温或癫痫发作。研究人员比较了肥胖(体重指数超过30)和非肥胖女性的子女之间的主要结局指标,并使用多变量logistic 回归估计调整后的比值比(OR)。

在6458名无糖尿病或高血压疾病的女性中,有3311名(51%)患者患有肥胖。调整人种后,肥胖患者的新生儿发生新生儿发病复合事件(9.2% vs. 7.2%,调整OR为1.39,95%CI为1.15-1.67)和神经性新生儿发病(0.7% vs. 0.3%,调整OR为2.84,95%CI为1.22-6.65)的风险显著增加。具体而言,肥胖患者的新生儿更容易出现缺氧缺血性脑病(0.5% vs. 0.2%,调整OR为2.80,95%CI为1.02-7.68)、低温治疗(0.6% vs. 0.2%,调整OR为2.92 95%CI为1.17 -7.30)和疑似败血症(7.6% vs. 5.8%,调整OR为1.45,95%CI为1.18-1.79)。

由此可见,在分娩患者中,即使没有高血压疾病或糖尿病,产妇肥胖也是导致新生儿发病增加的独立危险因素。

原始出处:


Polnaszek, Brock E, et al. Neonatal Morbidity in the Offspring of Obese Women Without Hypertension or Diabetes.Obstetrics & Gynecology.2018. https://journals.lww.com/greenjournal/Abstract/publishahead/Neonatal_Morbidity_in_the_Offspring_of_Obese_Women.97957.aspx

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    2019-02-23 yhy100200
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    2019-02-25 lifestar
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    2018-09-19 jyzxjiangqin

    高血压及糖尿病的治疗。

    0

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    2018-09-12 惠映实验室

    学习了,谢谢分享。

    0

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    2018-09-11 misszhang

    谢谢MedSci提供最新的资讯

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