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Gastroenterology:阿司匹林不能降低一般人群的胰腺癌风险

2017-12-11 zhangfan MedSci原创

研究认为,规律的使用阿司匹林以及其他非甾体抗炎药不能降低一般人群的胰腺癌风险,仅糖尿病患者可能从阿司匹林预防中获益,但该结果需要进一步研究确证

阿司匹林以及其他非甾体抗炎药(NSAIDs)可降低肠癌等多种肿瘤风险。近日研究人员考察了NSAIDs与胰腺癌风险之间的关系。

研究利用多变量调整Cox比例风险回归模型考察了阿司匹林以及其他NSAID使用与胰腺癌风险之间的关系,总计141940人参与研究。研究同时进行了病例对照研究,在394名胰腺癌患者以及784名对照志愿者中,考察胰腺癌确诊前组间血浆水杨酸浓度差异。

前瞻性队列研究中,1122名患者在420万随访年中确诊胰腺癌。阿司匹林以及其他NSAIDs不能降低胰腺癌风险。亚组分析显示,仅糖尿病患者规律的服用阿司匹林可降低胰腺癌风险(rr, 0.71; 95% CI, 0.54-0.94)。病例对照研究中,确诊前血浆水杨酸浓度与胰腺癌风险不相关(浓度前1/5与后1/5患者OR, 1.08; 95% CI, 0.72-1.61; P 0.81)。

研究认为,规律的使用阿司匹林以及其他非甾体抗炎药不能降低一般人群的胰腺癌风险,仅糖尿病患者可能从阿司匹林预防中获益,但该结果需要进一步研究确证。

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    2018-06-17 许安
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    2018-04-18 sjq027
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