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CIRC RES:社会融合与女性冠心病风险降低有啥关系!

2017-04-07 xing.T MedSci原创

由此可见,社会融合与女性CHD的发病率之间呈负相关,但在很大程度上可以通过生活方式/行为途径来解释。


更高的社会融合程度与较低的血管疾病死亡率相关; 然而,它是否与冠状动脉心脏病(CHD)发病相关,特别是在妇女中,并且这种相关性是否会因病例死亡而变化,目前尚不清楚。近日,血管领域权威杂志Circulation Research上针对这些问题发表了一篇研究文章。该研究旨在通过一个大型女性前瞻性队列来明确社会融合与CHD发病风险之间的相关性。

在护士健康研究(NHS研究)中的76362名妇女,招募时她们没有冠心病和卒中(1992年),并一直随访至2014年。社会整合是通过简单的每4年一次的Berkman-Syme社交网络指数来进行评估。研究终点包括非致死性心肌梗死(MI)和致死性CHD。

随访期间,共有2372例参与者发生了CHD。调整人口统计学指标、健康/医疗风险因素和抑郁症状后,研究人员发现社会融合与较低的CHD风险显著相关,特别是致死性CHD。社会融合最好的妇女与与社会融合度最差的妇女相比发生致死性CHD的风险比为0.55(95%可信区间为0.41-0.73)(趋势p<0.0001)。

当进一步调整生活方式行为时,有关致死性CHD的结果依旧存在,但有所减弱(趋势p=0.02),而非致死性心肌梗死与社会融合的显著关联不复存在。社会融合与非致死性心肌梗死风险之间的负相关性在很大程度上是可以通过健康促进行为来解释,特别是通过改变吸烟。然而,考虑到这些行为之后,与致死性CHD风险的相关性仍然存在,因此,可能涉及更直接的生物学机制。

由此可见,社会融合与女性CHD的发病率之间呈负相关,但在很大程度上可以通过生活方式/行为途径来解释。

原始出处:

Shun-Chiao Chang, et al. Social Integration and Reduced Risk of Coronary Heart Disease in Women: The Role of Lifestyle Behaviors.Circulation research. 2017. https://doi.org/10.1161/CIRCRESAHA.116.309443

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    2017-04-11 天涯183

    非常好的文章

    0

  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sat Apr 08 07:56:06 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185920, encodeId=da8518592079, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Apr 08 07:38:15 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185878, encodeId=a9d91858e8be, content=其实更多的联系仍要研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-04-09 licz0427
  5. 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  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 08 03:15:31 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-09 tofsw

    学习了谢谢分享

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sat Apr 08 07:56:06 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185920, encodeId=da8518592079, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Apr 08 07:38:15 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185878, encodeId=a9d91858e8be, content=其实更多的联系仍要研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 08 03:15:31 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-08 医艺依意

    社会因素是很多疾病的相关因素

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sun Apr 09 07:49:36 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185958, encodeId=4b04185958b7, content=社会因素是很多疾病的相关因素, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Apr 08 09:58:57 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185928, encodeId=110318592829, content=好好学习一下。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sat Apr 08 07:56:06 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185920, encodeId=da8518592079, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Apr 08 07:38:15 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185878, encodeId=a9d91858e8be, content=其实更多的联系仍要研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 08 03:15:31 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-08 tofsw

    好好学习一下。

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sat Apr 08 07:56:06 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185920, encodeId=da8518592079, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Apr 08 07:38:15 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185878, encodeId=a9d91858e8be, content=其实更多的联系仍要研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 08 03:15:31 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-08 刘煜

    学习了谢谢分享

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Sat Apr 08 07:56:06 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185920, encodeId=da8518592079, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Apr 08 07:38:15 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185878, encodeId=a9d91858e8be, content=其实更多的联系仍要研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Apr 08 03:15:31 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-08 雾夜芭蕾

    其实更多的联系仍要研究

    0

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