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Stem Cells:新研究在干细胞中找到“不老之泉”的奥秘

2016-07-27 佚名 生物谷

最近一项研究表明不老之泉的奥秘可能在于胚胎干细胞中一个叫Nanog的基因。“关于Nanog的研究帮助我们更好地理解衰老过程,最终知道如何逆转衰老。”文章作者Stelios T. Andreadis教授这样说道。为了对抗衰老,机体储备了一些具有器官再生能力的成体干细胞,这些干细胞位于机体的每个组织内,能够在需要的时候快速应答。但是随着人们年龄的增长,许多成体干细胞无法再很好地完成它们的工作,这就可能

最近一项研究表明不老之泉的奥秘可能在于胚胎干细胞中一个叫Nanog的基因。

“关于Nanog的研究帮助我们更好地理解衰老过程,最终知道如何逆转衰老。”文章作者Stelios T. Andreadis教授这样说道。

为了对抗衰老,机体储备了一些具有器官再生能力的成体干细胞,这些干细胞位于机体的每个组织内,能够在需要的时候快速应答。但是随着人们年龄的增长,许多成体干细胞无法再很好地完成它们的工作,这就可能导致衰老相关疾病的发生。因此逆转衰老对成体干细胞的影响,重新启动这些干细胞能够帮助克服这一问题。

Andreadis他们之前就发现成体干细胞形成肌肉的能力会随着衰老逐渐下降。

在这项新研究中,研究人员将Nanog导入衰老的干细胞中,发现Nanog开启了两条关键信号途径:ROCK和TGF-beta信号途径。这两条信号途径的激活推动了处于休眠状态的蛋白actin开始组装成体干细胞形成肌肉细胞所需要的细胞骨架。这些事件帮助因衰老而失去再生分化能力的成体干细胞重新获得干细胞特性。

Nanog不仅具有延缓衰老的能力,有些情况下甚至还有逆转衰老的潜能。研究人员在三种不同的衰老模型中对Nanog的作用进行了验证。除此之外他们还发现Nanog能够激活肌肉形成所需的一种重要调控因子——血清应答因子(SRF),这表明该研究的结果可能会在骨骼肌,心肌以及其他肌肉类型中得到应用。

研究人员现在正着重寻找能够替代或模拟Nanog作用的药物。如果能够发现这样的药物就能够让他们进一步研究在体内环境下衰老能否被逆转。研究人员表示这项研究对于从动脉粥样硬化,骨质疏松到阿尔茨海默病等许多疾病的治疗都有提示意义。

原始出处

Panagiotis Mistriotis1, Vivek K. Bajpai1, Xiaoyan Wang1, Na Rong1, Aref Shahini1, Mohammadnabi Asmani2, Mao-Shih Liang1, Jianmin Wang3, Pedro Lei1, Song Liu3, Ruogang Zhao2 andStelios T. Andreadis1,2,*.NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.Stem Cells.2016

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    2017-05-08 维他命
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