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BMJ:补充多不饱和脂肪酸对II型糖尿病的预防及治疗无意义

2019-08-22 MedSci MedSci原创

研究认为多不饱和脂肪酸对预防和治疗2型糖尿病无显著作用

近日研究人员评估omega-3、omega-6和总多不饱和脂肪酸(pufa)补充对糖尿病诊断和葡萄糖代谢的影响。

本次研究为系统回顾和荟萃分析,收集至少24周,评估补充α-亚麻酸、长链omega-3、omega-6或总PUFA对糖尿病诊断、空腹血糖或胰岛素、糖化血红蛋白(HbA1c)和/或胰岛素抵抗同态模型评估(HOMA-IR)的随机对照研究数据。

总计83项随机对照试验,主要是评估补充长链omega-3的效果。长链omega-3对糖尿病诊断 (RR=1.00)、糖代谢 (HbA1c平均差值-0.02%)、血糖、空腹胰岛素以及HOMA-IR无明显影响。当补充长链omega-3剂量大于4.4g/d时,观察到不良结果。α-亚麻酸、omega-6和总PUFA对糖尿病诊断的影响不明确,但对糖代谢的影响很小或没有影响,除了增加α-亚麻酸可增加空腹胰岛素(约7%)外。没有证据表明omega-3/omega-6比值对糖尿病或葡萄糖代谢很重要。

研究认为多不饱和脂肪酸对预防和治疗2型糖尿病无显著作用。

原始出处:


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    2020-01-10 gaoxiaoe
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    2019-08-22 misszhang

    谢谢MedSci提供最新的资讯

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研究发现,GLP-1受体激动剂治疗对II型糖尿病患者的心血管、死亡率和肾脏预后有益

JAMA Intern Med:持续改善糖尿病照护水平已刻不容缓

编者按:尽管在过去20年中,人们在药物研发及创新型糖尿病照护模式方面取得了长足的进步,但来自美国波士顿麻省总医院的研究人员发现,2005~2016年,全美糖尿病照护水平没有显著改善,与社会经济地位相关的照护差距持续存在。近期这项研究成果发表在JAMA内科杂志上。

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