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Oncotarget:中国传统药物是如何杀死癌细胞的

2016-09-09 佚名 来宝网

阿德莱德大学的研究人员目前从中国传统草药中得到了复杂混合物,经研究其具有杀死癌细胞的作用。本次研究结果发表在Oncotarget期刊上。复方苦参注射液(CKI)被中国批准用于治疗各种癌症,通常用作辅助西药化疗。但是这种药物的抗癌原理尚未得知。澳大利亚分子生物学专家David Adelson教授说道,“大部分中药的使用是基于中国人的传统经验。中药在一些疾病的治疗过程中疗效确实不错。但是没有人知道这些

阿德莱德大学的研究人员目前从中国传统草药中得到了复杂混合物,经研究其具有杀死癌细胞的作用。本次研究结果发表在Oncotarget期刊上。

复方苦参注射液(CKI)被中国批准用于治疗各种癌症,通常用作辅助西药化疗。但是这种药物的抗癌原理尚未得知。

澳大利亚分子生物学专家David Adelson教授说道,“大部分中药的使用是基于中国人的传统经验。中药在一些疾病的治疗过程中疗效确实不错。但是没有人知道这些药物治疗疾病的具体现代药理学机制。经试验,如果我们打破中药药方中的成分,会发现单个化合物不会起到很好的治疗效果,通常一些药物的组合才能够显效。本次研究的苦参注射液的成分十分复杂,它是从两种药材——苦参和白土苓根部提取而来。”

研究人员在实验室中利用乳腺癌细胞,采用下一代高通量测序技术对CKI影响的生物信号通路进行了测定。Adelson教授说道,“通过实验,我们发现CKI影响了西医化疗中影响的若干基因,它们具有共性。这些受影响的基因调节细胞的生存周期,这似乎是复方苦参注射液杀死癌细胞的可能机制。这项技术可以用来对中国传统药物起效的具体分子生物学机制进行现代化研究,为中药现代化提供新的思路。”

原始出处:

Qu Z, Cui J, Harata-Lee Y, Aung TN, Feng Q, Raison JM, Kortschak RD, Adelson DL.Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics.Oncotarget. 2016 Sep 1. doi: 10.18632/oncotarget.11788.

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    2016-10-31 ylzr123

    这项技术可以用来对中国传统药物起效的具体分子生物学机制进行现代化研究,为中药现代化提供新的思路。学习了,好文值得点赞!

    0

  2. 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    2016-10-22 晓风残月5386

    中医宝库,值得挖掘呀!

    0

  3. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-10-02 jyzxjiangqin

    传统医学具有优势。

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 14:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124967, encodeId=c8f812496ecd, content=将中医药发扬光大,走向世界。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 13 11:33:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124795, encodeId=01cc124e95b3, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2017-02-15 闆锋旦
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 14:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124967, encodeId=c8f812496ecd, content=将中医药发扬光大,走向世界。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 13 11:33:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124795, encodeId=01cc124e95b3, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-21 tinali1986

    单药的机制还没研究透彻,又来组合方了,更加复杂啦

    0

  6. 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15 11:02:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131975, encodeId=77bb1319e5ab, content=单药的机制还没研究透彻,又来组合方了,更加复杂啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Wed Sep 21 07:29:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125510, encodeId=3fe41255102f, content=希望尽快应用,让更多人受益。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160731/IMG579D7C0181B5E7069.jpg, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 14:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124967, encodeId=c8f812496ecd, content=将中医药发扬光大,走向世界。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 13 11:33:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124795, encodeId=01cc124e95b3, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 yonghu1

    希望尽快应用,让更多人受益。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 14:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124967, encodeId=c8f812496ecd, content=将中医药发扬光大,走向世界。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 13 11:33:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124795, encodeId=01cc124e95b3, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 doctorJiangchao

    继续关注

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 jyzxjiangqin

    将中医药发扬光大,走向世界。

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 14:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124967, encodeId=c8f812496ecd, content=将中医药发扬光大,走向世界。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 13 11:33:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124795, encodeId=01cc124e95b3, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Sep 13 11:10:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

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