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Diabetic Med:在贝尔法斯特的高糖血症和不良妊娠结局研究中孕期母亲维生素D和糖血症的标记

2018-10-25 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于在贝尔法斯特的高糖血症和不良妊娠结局研究中孕期母体维生素D和糖血症的标记的研究。研究人员测量参与贝尔法斯特高血糖和不良妊娠结局(HAPO)观察研究的妊娠中期妇女的总25-羟基维生素D水平,并研究25-羟基维生素D水平与妊娠糖尿病标志物mellitus和脂质标志物之间的关联。 本研究共对1585名孕妇有血清样本测量。作为HAPO研究

近日,国际杂志 《Diabetic Med》上在线发表一项关于在贝尔法斯特的高糖血症和不良妊娠结局研究中孕期母体维生素D和糖血症的标记的研究。研究人员测量参与贝尔法斯特高血糖和不良妊娠结局(HAPO)观察研究的妊娠中期妇女的总25-羟基维生素D水平,并研究25-羟基维生素D水平与妊娠糖尿病标志物mellitus和脂质标志物之间的关联。

本研究共对1585名孕妇有血清样本测量。作为HAPO研究的一部分,在妊娠24-32周从北爱尔兰贝尔法斯特皇家银禧妇产医院招募参与者。使用液相色谱串联质谱法测量25-羟基维生素D浓度。先前在中心实验室中分析了葡萄糖,C-肽和脂质水平。进行统计分析。

研究结果显示,怀孕期间中位数(四分位数间距)25-羟基维生素D浓度为38.624.1-60.7nmol/l65.8%的女性缺乏维生素D(≤50nmol/ l)。在回归分析中,母体25-羟基维生素D与空腹血糖水平之间的关联接近显著[回归系数-0.01795CI -0.0340.001; P = 0.06],并且在母体25-羟基维生素D和β细胞功能之间观察到显著的正相关[1.01395CI 1.0011.024; P=0.031]。回归分析中,母体25-羟基d水平与HDL [0.04795CI 0.021 0.073P 0.001]和总胆固醇[0.08595CI0.0020.167; P = 0.044]显著相关。

这些结果表明,怀孕期间维生素D缺乏症的患病率很高,需要进行分析和治疗; 然而,在25-羟基维生素D水平与葡萄糖和胰岛素代谢标志物之间仅观察到弱关联。这表明这些临床意义仍不明确。

原始出处:

C. CaseyA. McGintyV. A. Holmeset al. Maternal vitamin D and markers of glycaemia during pregnancy in the Belfast centre of the Hyperglycaemia and Adverse Pregnancy Outcome study

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    2018-10-26 wxl882001

    了解一下

    0

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    2018-10-25 医者仁心5538

    学习了

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