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Diabetes Care:2型糖尿病患者发病年龄与终末期肾脏疾病长期风险之间的关系

2020-06-16 网络 网络

2型糖尿病患者的ESKD长期风险很高,这对那些较年轻的糖尿病患者影响更大,因为他们糖尿病病程更长。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估2型糖尿病发病年龄对发病后ESKD累积发生率的影响。

该研究纳入了2002年至2013年期间澳大利亚国家糖尿病服务计划(NDSS)上登记的1113201名2型糖尿病患者。该NDSS与澳大利亚和新西兰的透析和移植登记中心以及澳大利亚国民死亡指数相链接。

2002年至2013年间,在7839075人次每年的随访期间,共发生了7592例ESKD事件。在糖尿病发病后的前10-15年中,ESKD的发生率在老年糖尿病患者中最高,而在糖尿病病程较长的情况下,ESKD的发生率在年轻糖尿病患者中更高。糖尿病发病在40岁之后的患者,诊断年龄为10-29岁和30-39岁的糖尿病患者ESKD累积发生率分别为11.8%和9.3%。如果包含未经肾脏替代治疗的ESKD死亡病例,在发病最初的20年中,高龄糖尿病患者ESKD的发生率仍较高,此后发病年龄无明显影响。

由此可见,2型糖尿病患者的ESKD长期风险很高,这对那些较年轻的糖尿病患者影响更大,因为他们糖尿病病程更长。

原始出处:

Jedidiah I. Morton.et al.The Association Between Age of Onset of Type 2 Diabetes With the Long-term Risk of End-Stage Kidney Disease: A National Registry Study.Diabetes Care.2020.https://doi.org/10.2337/dc20-0352

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    2020-06-16 misszhang

    谢谢MedSci提供最新的资讯

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