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CLIN CANCER RES：瘤内注射DC细胞可以改善肿瘤患者预后

2018-08-28 MedSci MedSci原创

DC细胞细胞因子瘤内注射
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树突状细胞（DC）通过抗原呈递激活继发免疫反应。临床前研究表明，瘤内注射活化DCs（aDCs；DCVax-Direct）的抑瘤效果优于不成熟DCs。CLIN CANCER RES近期发表了一篇文章，报道了瘤内注射aDCs治疗肿瘤临床试验的结果。

树突状细胞（DC）通过抗原呈递激活继发免疫反应。临床前研究表明，瘤内注射活化DCs（aDCs；DCVax-Direct）的抑瘤效果优于不成熟DCs。CLIN CANCER RES近期发表了一篇文章，报道了瘤内注射aDCs治疗肿瘤临床试验的结果。

该试验主要评估瘤内注射aDCs治疗实体肿瘤患者的安全性和有效性。使用标准的3+3设计，共3个剂量水平（每次注射aDCs2百万，6百万和一千五百万）。评估该疗法的可行性，免疫原性，注射后肿瘤微环境的改变情况以及患者生存情况。作者还研究了aDCs注射前细胞因子分泌情况。共入组40例患者， 其中39例可进行评估。瘤内注射aDCs耐受性良好，无剂量限制毒性。54%的患者中观察到淋巴细胞浸润增加。第8周病情稳定与总生存改善有关。aDCs分泌的IL-8和IL12p40增加与预后显着相关。分泌TNFα水平升高与第8周病情稳定正相关。

文章最后认为，瘤内aDCs注射安全可行。特定的细胞因子分泌增加与病情稳定和生存改善有关，因此注射前aDCs的功能与患者结局之前存在联系。

原始出处：
Vivek Subbiah,Ravi Murthy,et al.Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers.CLIN CANCER RES.August 2018 doi:10.1158/1078-0432.CCR-17-2707

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    2018-11-15 13718711b3m

    非常不错的学习资料，值得借鉴的临床经验，学习了，获益匪浅，感谢分享！

    0

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    2018-10-22 13718711b3m

    学习了，涨知识，非常不错的临床经验，值得借鉴，受益匪浅，感谢分享！

    0

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    2019-06-04 bnurmamat

    #患者预后#

    0

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    2018-08-30 lanyan20020087

    #肿瘤患者#

    0

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    2018-08-30 zhangyxzsh

    #DC细胞#

    0

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    2018-08-30 明月清辉

    谢谢分享，学习了

    0

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    2018-08-29 kafei

    学习了谢谢

    0

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