Int J Cardiol：抑郁和焦虑症状加重在接受口服抗凝治疗患者的死亡风险

2015-05-26 徐媛媛译 MedSci原创

在患有心血管疾病的患者中患有抑郁和焦虑症现象非常普遍。本文研究人员通过使用PHQ-4评估了长期接受口服抗凝药物(OAC)患者的全因死亡率。研究人员收纳了接受维生素K拮抗剂长期口服抗凝治疗的患者1384名。在基线,使用PHQ-4评估了患者的焦虑和抑郁症状及患者用药史，最终结局以24个月内的全因死亡率，中位随访时间为13.3个月。在收纳的1384名患者中有191名死亡(最终死亡率为13.8%)

在患有心血管疾病的患者中患有抑郁和焦虑症现象非常普遍。本文研究人员通过使用PHQ-4评估了长期接受口服抗凝药物(OAC)患者的全因死亡率。

研究人员收纳了接受维生素K拮抗剂长期口服抗凝治疗的患者1384名。在基线,使用PHQ-4评估了患者的焦虑和抑郁症状及患者用药史，最终结局以24个月内的全因死亡率，中位随访时间为13.3个月。

在收纳的1384名患者中有191名死亡(最终死亡率为13.8%)。在校正年龄、性别、教育水平、吸烟、肥胖、虚弱程度（巴氏量表与查尔森合并症指数）与CHA2DS2-VASc后，PHQ-4每增加1分死亡率增加10%（HR = 1.1；95% CI，1.05-1.16）。抑郁（PHQ-2）和焦虑(GAD-2)使患者死亡率分别增加22%和11%。精神障碍用药史、抗抑郁药、抗焦虑药或安眠药物均与超额死亡率无关。

在接受长期口服抗凝治疗的门诊患者中，抑郁与焦虑症状加重与患者的全因死亡有关。PHQ-4问卷提供了有价值的预后信息，这些PHQ-4问卷信息强调了需要实施定期检查程序和适当的心理治疗法。

原始出处

Michal M1, Prochaska JH2, Keller K2, Göbel S3, Coldewey M2, Ullmann A4, Schulz A5, Lamparter H4, Münzel T3, Reiner I6, Beutel ME6, Wild PS7.Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program.Int J Cardiol. 2015 May

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2015-08-06 仁者大医

#Cardiol#

73 0
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2016-03-15 日月

#口服抗凝治疗#

85 0
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2015-05-31 huaxipanxing

看看

147 0
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2015-05-31 kuibaoli

其他疾病也应该关注这个问题

146 0
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2015-05-28 quxin068

#死亡风险#

76 0
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2015-05-27 warmniu

interesting

161 0
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2015-05-26 panky0526

我们的研究中更多的是使用PHQ9量表

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