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PNAS:长链非编码RNA对脑生长起重要作用

2018-10-12 小通 生物通

Scripps 研究所的Sathyanarayanan Puthanveettil课题组在《PNAS》的一项研究指出,深眠于发育中的脑细胞核内的长链非编码RNAs对维持突触健康运行起重要作用。

Scripps 研究所的Sathyanarayanan Puthanveettil课题组在《PNAS》的一项研究指出,深眠于发育中的脑细胞核内的长链非编码RNAs对维持突触健康运行起重要作用。



“长非编码RNA通常被描述为‘基因组的暗物质’。在这里,我们系统地研究了它们对大脑发育、长期记忆储存、衰老和痴呆导致的记忆力下降的分子机制,”Puthanveettil说。

RNA是细胞的主要调节因子,是读取、转录和调节DNA表达以及构建蛋白质的小型核苷酸链,虽然科学家们已经掌握了脑细胞之间如何相互接触和沟通的基本遗传知识,但是对这类非编码RNAs(长达200个核苷酸)的作用了解甚少,它们的功能是开启/关闭大脑细胞中某些基因,到底调控哪些基因呢?

新研究发现一种名为GM12371的长链非编码RNA可以控制神经系统发育和功能多种基因表达,它还影响发育中的神经元的形状和信号发射能力。

在小鼠海马细胞中,学习相关信号可以上调GM12371,而其减产会失活神经元,表现为神经元分支稀疏。

这些结果表明,脑细胞和脑回路的健康生长和发育不仅取决于特定蛋白质,还取决于现在正在探索的特定长链非编码RNA。

GM12371在大脑和神经系统疾病中扮演什么角色还需要进一步研究。“越来越多证据表明,编码和非编码RNAs具有用药潜质,在我们确定了它们在神经回路功能方面的生物学作用后,最终将为治疗自闭症和阿尔兹海默症等神经精神疾病开辟新途径,”Puthanveettil说。

原始出处:Raveendra BL1, Swarnkar S1, Avchalumov Y1, et al. Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function. Proc Natl Acad Sci U S A. 2018 Oct 8. 

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    2019-09-08 d830384
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    2019-03-22 爆笑小医
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1743478, encodeId=82081e4347803, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Sun Sep 08 11:24:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023528, encodeId=694920235281a, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Thu Mar 21 17:24:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1856227, encodeId=ec64185622eb2, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Mar 22 14:24:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485825, encodeId=4307148582566, content=<a href='/topic/show?id=d0f29e089a9' target=_blank style='color:#2F92EE;'>#长链非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97089, encryptionId=d0f29e089a9, topicName=长链非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5df38055979, createdName=minhuang75_72521586, createdTime=Sat Oct 13 17:24:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584716, encodeId=d9a51584e16f6, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Sat Oct 13 17:24:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349003, encodeId=7ccf34900397, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Oct 12 08:17:55 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348966, encodeId=cd5b34896685, content=谢谢分享,学习了谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 12 06:33:53 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348963, encodeId=9cc134896344, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Oct 12 05:42:51 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
    2018-10-12 kafei

    学习了谢谢

    0

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    2018-10-12 明月清辉

    谢谢分享,学习了谢谢分享,学习了

    0

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