JCEM：绝经后妇女同型半胱氨酸代谢与脊柱骨关节炎进展风险之间的关系

2021-08-12 MedSci原创 MedSci原创

尽管同型半胱氨酸积累是几种与年龄有关疾病的危险因素，但对其与骨关节炎(OA)之间的关系知之甚少。

尽管同型半胱氨酸积累是几种与年龄有关疾病的危险因素，但对其与骨关节炎(OA)之间的关系知之甚少。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，该研究旨在通过横断面和纵向队列研究相结合，探究同型半胱氨酸和亚甲基四氢叶酸还原酶(MTHFR)的C677T多态性与脊柱OA的发生和进展之间的关联。

该研究共有1306名参与长野队列研究的日本绝经后女性，她们接受了平均9.7年的随访。根据血清同型半胱氨酸水平对登记时的脊柱OA患病率进行横断面多元Logistic回归，并调整了混杂因素。除了Kaplan-Meier分析外，研究人员还采用多变量Cox回归来评估MTHFR的C677T变异对脊柱OA进展的独立风险。

多变量回归分析发现同型半胱氨酸与脊柱OA患病率之间存在显著关联（比值比为1.38；95%置信区间[CI]为1.14-1.68）。Kaplan-Meier曲线发现MTHFR的C677T多态性中T等位基因对脊柱OA严重程度加速进展存在基因剂量效应（P=0.003）。Cox回归分析验证了T等位基因对脊柱OA进展具有统计学意义的独立风险。CT/TT和TT基因型的调整后风险比分别为1.68(95%CI为1.16-2.42)和1.67(95%CI为1.23-2.28)。

由此可见，循环同型半胱氨酸和MTHFR的C677T变异分别与脊柱OA的患病率和随后的进展相关。这些因素可能代表预防OA发展和改善临床结局的潜在干预靶标。

原始出处：

Masaki Nakano.et al.Associations of homocysteine metabolism with the risk of spinal osteoarthritis progression in postmenopausal women.JCEM.2021.https://doi.org/10.1210/clinem/dgab591

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2023-03-09 showtest 来自上海

绝经后妇女#同型半胱氨酸##代谢#与#脊柱骨关节炎#进展风险之间的关系#骨关节炎#

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2021-11-29 仁者大医

#JCEM#

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2022-01-05 lisa438

#骨关节#

57 0
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ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1778100, encodeId=47c31e781008d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Mon Nov 29 04:28:48 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026704, encodeId=32bb2026e04ca, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332028, encodeId=b48513320284f, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631651, encodeId=457c16316515b, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=)]
2022-06-29 achengzhao

#JCE#

49 0
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2021-08-14 小小的丁香花

学习了

77 0
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2021-08-14 yeye5224612

#绝经#

61 0
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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332028, encodeId=b48513320284f, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631651, encodeId=457c16316515b, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=)]
2021-08-14 lmm397

#关节炎#

52 0
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createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 14 23:30:18 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257278, encodeId=467a125e27893, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266302, encodeId=3aae12663024e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, 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href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=)]
2021-08-14 108807375_62823127

#绝经后妇女#

73 0
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createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 14 23:30:18 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257278, encodeId=467a125e27893, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266302, encodeId=3aae12663024e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332028, encodeId=b48513320284f, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631651, encodeId=457c16316515b, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sat Aug 14 12:28:48 CST 2021, time=2021-08-14, status=1, ipAttribution=)]
2021-08-14 zxxiang

#绝经后#

46 0

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JCEM：绝经后妇女同型半胱氨酸代谢与脊柱骨关节炎进展风险之间的关系

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