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Neurology:无心血管疾病的老年妇女血压变异性与脑形态的关系

2019-03-01 xing.T 网络

由此可见,在没有可改变心血管危险因素的绝经后妇女中,较大的随访收缩压BPV与海马体积减少和晚年病变体积增加有关。这些数据为BPV作为预后指标提供了证据,即使没有已知的心血管危险因素。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,该研究旨在评估几乎没有可改变的血管危险因素的绝经后妇女血压(BP)变异性(BPV)、脑容量和认知功能之间的关系。

研究参与者包括参加妇女健康倡议记忆MRI研究(WHIMS-MRI)的绝经后妇女,这些参与者在基线时没有血管疾病、糖尿病高血压或吸烟(1996-1999)。血压读数是在基线和每年的随访时进行的。BPV被定义为与参与者随访期间的平均血压相关的SD,以及与参与者的回归线相关的SD。在2004年至2006年期间进行脑MRI扫描。在基线时评估认知功能,之后每年使用改良的简易精神状态检查(3MSE)评分进行测量,直至2008年。最终样本由558名女性组成(平均年龄69岁,中位随访时间[四分位数间距]为8[0.8]年)。

在包括平均收缩压的调整模型中,与最低三分位数的女性相比,收缩压BPV最高三分位数的女性具有较低的海马体积和较高的病变体积。没有检测到BPV与3MSE评分之间的关​​系。

由此可见,在没有可改变心血管危险因素的绝经后妇女中,较大的随访收缩压BPV与海马体积减少和晚年病变体积增加有关。这些数据为BPV作为预后指标提供了证据,即使没有已知的心血管危险因素。

原始出处:

Bernhard Haring,et al.Blood pressure variability and brain morphology in elderly women without cardiovascular disease.Neurology. 2019.https://doi.org/10.1212/WNL.0000000000007135

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    2020-01-12 yinhl1978
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1717658, encodeId=53e31e1765815, content=<a href='/topic/show?id=d0cd80153d2' target=_blank style='color:#2F92EE;'>#老年妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80153, encryptionId=d0cd80153d2, topicName=老年妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 05 13:41:00 CST 2020, time=2020-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000723, encodeId=a5272000e23f3, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jan 12 23:41:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810395, encodeId=70e51810395e7, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Mon May 20 23:41:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342564, encodeId=945c13425649c, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Mar 03 00:41:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498540, encodeId=faeb149854012, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Mar 03 00:41:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031138, encodeId=dc44103113879, content=#血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 01 12:41:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361779, encodeId=779e361e792f, content=学习一下新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Mar 01 11:24:55 CST 2019, time=2019-03-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1717658, encodeId=53e31e1765815, content=<a href='/topic/show?id=d0cd80153d2' target=_blank style='color:#2F92EE;'>#老年妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80153, encryptionId=d0cd80153d2, topicName=老年妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 05 13:41:00 CST 2020, time=2020-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000723, encodeId=a5272000e23f3, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jan 12 23:41:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810395, encodeId=70e51810395e7, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Mon May 20 23:41:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342564, encodeId=945c13425649c, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Mar 03 00:41:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498540, encodeId=faeb149854012, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Mar 03 00:41:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031138, encodeId=dc44103113879, content=#血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 01 12:41:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361779, encodeId=779e361e792f, content=学习一下新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Mar 01 11:24:55 CST 2019, time=2019-03-01, status=1, ipAttribution=)]
    2019-03-01 心介

    #血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以

    0

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    2019-03-01 flysky120

    学习一下新知识

    0

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