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JAHA:绝经后妇女25-羟基维生素D和甲状旁腺激素水平的种族差异和心血管疾病风险

2019-02-18 xing.T 网络

由此可见,维生素D生物标志物的循环水平与白人或黑人女性的心血管疾病风险无关。较高的甲状旁腺激素水平可能是白人女性心血管疾病的独立危险因素。

最近的证据表明游离或生物可利用的25-羟基维生素D(25[OH]D)而不是总25(OH)D的循环水平的种族/民族差异可以解释血管疾病(CVD)中明显的种族差异。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员
前瞻性地评估了基线时全部、游离和生物可利用的25(OH)D、维生素D结合蛋白和甲状旁腺激素水平与发生CVD(包括非致死性心肌梗死、非致死性卒中和CVD死亡)黑人和白人绝经后妇女之间的差异。

研究人员对79705名绝经后妇女进行了一项病例队列研究,这些妇女年龄在50至79岁之间,在WHI-OS(女性健康倡议观察研究)中基线没有CVD。研究人员随机选择1300名黑人和1500名白人参与者的子群体作为对照;共选择了550名黑人和1500名白人女性在11年的平均随访期间发生了CVD事件。研究人与那直接测量了总25(OH)D、维生素D结合蛋白、白蛋白、甲状旁腺激素,并计算了游离和生物可利用的25(OH)D水平。加权Cox比例风险模型用于评估它们与CVD风险的关联。

虽然维生素D结合蛋白和总的、游离和生物可利用的25(OH)D与黑人或白人女性的心血管疾病风险没有显著相关,但白人女性中甲状旁腺激素和心血管疾病风险之间存在显著正相关(最高与最低四分位数个体的风险比为1.37; 95%CI为1.06-1.77),但黑人女性则不然(最高与最低四分位数个体的风险比为1.12; 95%CI为0.79-1.58),与总的、游离和生物可利用的25(OH)D或维生素D结合蛋白无关。

由此可见,维生素D生物标志物的循环水平与白人或黑人女性的心血管疾病风险无关。较高的甲状旁腺激素水平可能是白人女性心血管疾病的独立危险因素。

原始出处:

Xi Zhang.et al.Racial/Ethnic Differences in 25‐Hydroxy Vitamin D and Parathyroid Hormone Levels and Cardiovascular Disease Risk Among Postmenopausal Women.JAHA.2019.https://www.ahajournals.org/doi/10.1161/JAHA.118.011021

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    2019-02-20 zhaohui6731
  4. 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  5. 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    2019-02-20 zxxiang
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    2019-02-18 183****7028

    学习

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JAHA:母乳喂养史与绝经后妇女卒中风险

由此可见,该研究的结果显示,在调整多发性卒中危险因素和生活方式变量后,绝经后妇女母乳喂养与卒中风险降低之间存在关联,并且呈剂量反应关系。

Heart:女性生育因素可影响心血管疾病发生风险

既往研究报道女性生育因素与心血管疾病(CVD)发生风险呈相关性,但结果一致性较差。本研究的目的旨在评估英国地区女性生育因素与CVD发生的相关性。2006年至2010年,英国生物样本库招募了超过500000名40-69岁的女性,经过7年时间的随访,共有9054例CVD事件发生(女性占34%),5782例冠心病事件发生(女性占28%),3489例卒中事件发生(女性占43%),通过Cox回归模型分析了C

Gastroenterology :外源性激素与女性致显微镜下结肠炎风险

女性使用外源性激素导致显微镜下结肠炎风险增加

Eur Respir J:较低DHEA-S水平可预测绝经后女性肺动脉高压和预后

由此可见,较高的E2和较低的DHEA-S水平与绝经后妇女中PAH的风险和严重程度相关。激素调节应作为PAH治疗策略进一步研究。

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