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Lancet Infect Dis: 唾液中2019-nCOV的检测及COVID-19患者的口腔症状

2020-03-31 网络 网络

唾液口干2019-nCoV味觉异常COVID-19患者
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由一种新的冠状病毒(2019-NCOV)引起的冠状病毒疾病19(Covid-19)已被世界卫生组织(WHO)归类为大流行病。 据报道，2019-NCOV可以在各种人类分泌和排泄物中检测到，如痰、粪便和

由一种新的冠状病毒(2019-NCOV)引起的冠状病毒疾病19(Covid-19)已被世界卫生组织(WHO)归类为大流行病。 据报道，2019-NCOV可以在各种人类分泌和排泄物中检测到，如痰、粪便和尿液。 然而，到目前为止，唾液中2019-NCOV的检测还没有报道。 为了更全面地了解2019-nCOV对口腔健康的影响和可能的唾液传播，本研究收集了四个公共数据集(包括GTEx数据集、HPA数据集、FANTOM5数据集和Consensus数据集)的大量RNA-seq数据，分析了ACE2(血管紧张素转换酶II)受体在唾液腺上皮细胞中的表达。 并且招募了31名COVID-19患者，其2019-NCOV核酸检测在样本收集前或收集当天均为阳性，其中有4例危重病例，口咽拭子测试阳性。 从清洁口腔的唾液腺管口收集唾液，以避免呼吸道其他分泌物污染， 同时采集口咽拭子。 然后用RT-PCR检测唾液中2019-nCOV核酸的存在情况。此外， 为了评估COVID-19患者的口腔健康状况，对2020年2月28日至3月4日期间108名COVID-19患者的口腔相关症状进行问卷调查。

结果发现，ACE2在正常唾液腺组织中有一定的表达。有趣的是，我们发现4例唾液中2019-nCOV核酸的阳性检测，其中3例是需要呼吸机支持的危重患者，这意味着危重患者唾液阳性检出率高达75%。 同时，两种主要的口腔相关症状，口干（46.3%)和味觉异常(47.2%）发生率较高。

本研究证实了ACE2在唾液腺中的表达，并证明了唾液中检出2019-nCOV的可能性。其中，危重病人唾液阳性检出率高达75%（3/4）可能是由于病毒侵袭引起的高病毒载量或在疾病晚期破坏唾液腺。 唾液中病毒颗粒的出现可能表明患者的疾病状况恶化并进展到终末期。同时，由于唾液可以很容易地收集，没有任何侵入性操作，因此，唾液具有作为危重患者诊断的潜力。此外，患者中口干和味觉异常较高的发生率也表明口腔症状也可能是COVID-19感染的初始症状之一。

原始出处：

Chen， Lili and Zhao， Jiajia and Peng， Jinfeng， Detection of 2019-nCoV in Saliva and Characterization of Oral Symptoms in COVID-19 Patients. Lancet Infectious Diseases. March 14， 2020. Doi： 10.2139/ssrn.3557140

 

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    2020-09-17 cmj8wellington

    #Dis#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2013253, encodeId=358a20132537e, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Sep 17 14:25:15 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830562, encodeId=ba98183056251, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Apr 15 08:25:15 CST 2020, time=2020-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381266, encodeId=7fc738126683, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 02 18:41:56 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297419, encodeId=9fde129e41908, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Apr 02 07:25:15 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2020-04-15 howi

    #Lancet#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2013253, encodeId=358a20132537e, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Sep 17 14:25:15 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830562, encodeId=ba98183056251, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Apr 15 08:25:15 CST 2020, time=2020-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381266, encodeId=7fc738126683, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 02 18:41:56 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297419, encodeId=9fde129e41908, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Thu Apr 02 07:25:15 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2020-04-02 wxl882001

    了解一下

    0

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    2020-04-02 zhangph

    #COVID-19患者#

    0

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