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DIABETOLOGIA:前列腺素E2/EP2受体信号通路在糖尿病大鼠模型中促进糖尿病视网膜病变

2019-05-06 不详 网络

糖尿病视网膜病变是由炎症和凋亡相关的视网膜内皮细胞损伤引起的糖尿病常见的微血管并发症。前列腺素E2 (PGE2)是这些生物过程的关键调控因子。本研究假设调节PGE2及其E-prostanoid受体(EP2R)可以预防糖尿病mellitus引起的炎症和微血管功能障碍。

糖尿病视网膜病变是由炎症和凋亡相关的视网膜内皮细胞损伤引起的糖尿病常见的微血管并发症。前列腺素E2 (PGE2)是这些生物过程的关键调控因子。本研究假设调节PGE2及其E-prostanoid受体(EP2R)可以预防糖尿病mellitus引起的炎症和微血管功能障碍。

在链脲佐菌素(STZ)诱导的糖尿病大鼠模型中,大鼠接受玻璃体内注射PGE2butaprost (PGE2/EP2R激动剂)AH6809 (EP2R拮抗剂)。随后研究人员对视网膜组织学、光学相干层析、视网膜血管超微结构及生化指标进行评价。

玻璃体腔注射PGE2和丁胱甘肽可明显加速stz诱导的糖尿病大鼠视网膜血管渗漏、白细胞稳定和内皮细胞凋亡。经AH6809预处理的糖尿病大鼠的这种反应得到了改善。此外,用AH6809减毒PGE2-和丁糖原诱导的caspase 1活化、包含核苷酸结合域和富含亮氨酸重复序列的复合物的活化、包含3pyrin结构域(NLRP3)以及包含ccaspase活化和募集结构域(ASC)的凋亡相关斑点样蛋白对人视网膜微血管内皮细胞进行预处理,激活ep2r偶联cAMP/蛋白激酶A/cAMP反应元件结合蛋白信号通路。

PGE2/EP2R信号通路参与stz诱导的糖尿病视网膜病变,可能成为糖尿病视网膜病变防治的潜在靶点。

原始出处:

Man WangYangningzhi WangTianhua XieProstaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2021-07-16 星晓

    新机制和方向

    0

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createdBy=6e7035453721, createdName=makuansheng, createdTime=Mon Jun 03 20:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270190, encodeId=183a12e019000, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413983, encodeId=bb2e141398301, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539743, encodeId=7e6d1539e43e3, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569533, encodeId=61ee1569533ef, content=<a href='/topic/show?id=62ff32560b5' target=_blank style='color:#2F92EE;'>#前列腺素E2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32560, encryptionId=62ff32560b5, topicName=前列腺素E2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d4015518959, createdName=budeshao, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042420, encodeId=a61d104242099, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047705, encodeId=cf6d104e7051c, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1000159, encodeId=5543100015950, content=新机制和方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4f42486110, createdName=星晓, createdTime=Fri Jul 16 20:50:10 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639098, encodeId=c24b1639098ce, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 07 23:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761106, encodeId=472a1e611069d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Nov 30 19:53:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744858, encodeId=b9a31e448589d, content=<a href='/topic/show?id=37c3325555a' target=_blank style='color:#2F92EE;'>#前列腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32555, encryptionId=37c3325555a, topicName=前列腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e7035453721, createdName=makuansheng, createdTime=Mon Jun 03 20:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270190, encodeId=183a12e019000, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413983, encodeId=bb2e141398301, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539743, encodeId=7e6d1539e43e3, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569533, encodeId=61ee1569533ef, content=<a href='/topic/show?id=62ff32560b5' target=_blank style='color:#2F92EE;'>#前列腺素E2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32560, encryptionId=62ff32560b5, topicName=前列腺素E2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d4015518959, createdName=budeshao, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042420, encodeId=a61d104242099, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047705, encodeId=cf6d104e7051c, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
    2019-05-08 zutt
  6. 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likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1000159, encodeId=5543100015950, content=新机制和方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4f42486110, createdName=星晓, createdTime=Fri Jul 16 20:50:10 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639098, encodeId=c24b1639098ce, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 07 23:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), 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likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1000159, encodeId=5543100015950, content=新机制和方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4f42486110, createdName=星晓, createdTime=Fri Jul 16 20:50:10 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639098, encodeId=c24b1639098ce, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 07 23:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), 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beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32560, encryptionId=62ff32560b5, topicName=前列腺素E2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d4015518959, createdName=budeshao, createdTime=Wed May 08 13:53:00 CST 2019, time=2019-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042420, encodeId=a61d104242099, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047705, encodeId=cf6d104e7051c, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, 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    2019-05-07 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue May 07 01:53:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
    2019-05-07 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0

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