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Hypertension:磁共振成像评估的主动脉弓脉搏波速度作为心血管事件的预测指标!

2017-07-04 xing.T MedSci原创

由此可见,磁共振成像评估的主动脉弓PWV是中年(45-54岁)个体心血管事件的重要预测因子,而在一个多种族人群中主动脉弓PWV与老年心血管疾病并不存在相关性。

通过磁共振成像评估的主动脉弓脉搏波传导速度(PWV)对心血管疾病(CVD)事件的预测价值尚未完全建立。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究的目的是通过MESA研究(动脉粥样硬化的多民族研究)评估主动脉弓PWV与心血管病事件发生之间的相关性。

研究人员使用磁共振成像测量了来自于MESA研究的3527名无明显心血管疾病的参与者基线的主动脉弓PWV(基础平均年龄为62±10岁,47%为男性)。研究人员采用Cox回归评估了发生心血管事件(冠心病、脑卒中、短暂性脑缺血发作或心脏衰竭)的风险与主动脉弓PWV的相关性,在调整了年龄、性别、种族和心血管疾病的危险因素。

研究人员发现主动脉弓PWV的平均值为7.4m/s(四分位间距范围为5.6-10.2)。主动脉弓PWV与年龄之间对于结局存在显著的交互作用,所以分析是由年龄段进行分层(45-54岁和>54岁)。在10年随访中发生了456次心血管事件。45到54岁的参与者的主动脉弓PWV与独立于心血管病危险因素的心血管事件有着显著的相关性(PWV每增加1个对数变换,风险比为1.44;95%可信区间为1.07-1.95;P=0.018),而对于>54岁的患者则没有(P=0.93)。

由此可见,磁共振成像评估的主动脉弓PWV是中年(45-54岁)个体心血管事件的重要预测因子,而在一个多种族人群中主动脉弓PWV与老年心血管疾病并不存在相关性。

原始出处:

Yoshiaki Ohyama,et al. Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events The MESA (Multi-Ethnic Study of Atherosclerosis).Hypertension.2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08749

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createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 19 01:35:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643478, encodeId=8e8616434e8d8, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Oct 26 04:35:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222042, encodeId=8681222042e3, content=好文章学习并分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jul 14 06:45:34 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219019, encodeId=6b4f219019ea, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jul 06 06:41:39 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218983, encodeId=33a4218983f8, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jul 06 05:45:43 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341568, encodeId=fc331341568ea, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407000, encodeId=2c66140e00044, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415160, encodeId=3e1a141516096, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-14 大爰

    好文章学习并分享!

    0

  5. 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href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415160, encodeId=3e1a141516096, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  6. 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time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 大爰

    学习了谢谢分享!!

    0

  7. 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脉搏波传导速度(PWV)可影响抗高血压药物对心血管疾病的预防作用。PWV或PWV和血压控制是否是卒中的独立预测因子研究较少。纵向分析检测臂踝PWV(baPWV),血压控制及baPWV和血压控制对首发卒中风险的作用。本报告包括中国脑卒中一级预防试验的亚组中(CSPPT)3310例高血压成年人,检测基线baPWV。随访时间的中位数为4.5年,111受试者发生卒中。与baPWV最低四分位数的受试者相比,

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