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Hypertension:高baPWV和血压控制不良的患者,发生卒中风险**

2016-06-02 MedSci MedSci原创

脉搏波传导速度(PWV)可影响抗高血压药物对心血管疾病的预防作用。PWV或PWV和血压控制是否是卒中的独立预测因子研究较少。纵向分析检测臂踝PWV(baPWV),血压控制及baPWV和血压控制对首发卒中风险的作用。本报告包括中国脑卒中一级预防试验的亚组中(CSPPT)3310例高血压成年人,检测基线baPWV。随访时间的中位数为4.5年,111受试者发生卒中。与baPWV最低四分位数的受试者相比,

脉搏波传导速度(PWV)可影响抗高血压药物对心血管疾病的预防作用。PWV或PWV和血压控制是否是卒中的独立预测因子研究较少。纵向分析检测臂踝PWV(baPWV),血压控制及baPWV和血压控制对首发卒中风险的作用。

本报告包括中国脑卒中一级预防试验的亚组中(CSPPT)3310例高血压成年人,检测基线baPWV。随访时间的中位数为4.5年,111受试者发生卒中。与baPWV最低四分位数的受试者相比,baPWV最高四分位数卒中发生的风险高(6.3% vs 2.4%;HR,1.66;95%CI,1.06-2.60)。
相同的,血压控制不足的受试者发生卒中的风险高于血压充分控制的患者(5.1% vs 1.8%;HR,2.32;95% CI,1.49-3.61)。当将baPWV和血压控制联合进行分析发现,最高四分位数baPWV和血压控制不足的受试者卒中发生的风险高于baPWV最低四分位数和血压控制良好的受试者(7.5% vs 1.3%;HR,3.57;95%CI,1.88-6.77)。血压控制良好的患者,高baPWV对卒中显著独立的影响(4.2% vs 1.3%;HR 2.29,95%CI,1.09-4.81)。


总之,高血压患者中,baPWV,血压控制及baPWV联合血压控制都能影响首次卒中的发生。高baPWV和血压控制不良的参与者,发生卒中的风险最高。

原始出处:

Song Y, Xu B, Xu R, et al. Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults. Hypertension. 2016 May 23.

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    2016-10-13 ylzr123

    拜读了,受益匪浅,点个赞!

    0

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    2017-04-26 feather89
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    2016-06-03 医路开来

    很不错

    0

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