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BMJ子刊:妊娠期糖尿病需要注意筛查哪些代谢指标?与代谢综合征的发病相关性又如何?速戳!

2021-11-15 MedSci原创 MedSci原创

对产后糖尿病进行为期1年的筛查是绝对必要的。

有研究称妊娠期糖尿病(GDM)与冠状动脉钙化或未来血管事件增加两倍风险相关。早期研究报告,产后糖尿病(PP)早期(6-8周),代谢综合征(MetS)的患病率增加15%-20%,在随后几年,增加了40%-50%。MetS的存在与心血管疾病和全因死亡率增加3-4倍相关。以往公布的数据没有提及其组成部分或特定体重指数(BMI)类别的轨迹。因此,有必要在怀孕期间和怀孕后进行详尽的代谢评估,以便在这一高危人群中制定有针对性的干预措施。

一家大学妊娠糖尿病诊所在2011-2017年间对622名女性进行了这项前瞻性队列研究,并从2015年开始,对162名晚期产后访视的患者进行了一项长期队列研究。代谢综合征(MetS)是以国际糖尿病联合会的定义为基础的。

结果显示,与孕前相比,产后早期体重保持率为4.8±6.0 kg,肥胖、糖尿病前期、MetS体重指数(BMI)和MetS腰围(WC)的患病率分别为28.8%、28.9%、10.3%和23.8%。与产后早期相比,产后晚期体重无变化,腰围下降 2.6±0.6cm。然而,肥胖、糖尿病前期、MetS WC和MetS BMI的患病率增加

肥胖、糖尿病前期和MetS-WC的预测因子

肥胖的预测因素是怀孕期间使用降糖治疗和孕前BMI糖尿病前期的预测因素是产后早期空腹血糖值和糖尿病家族史。最后,妊娠期和产后早期的收缩压、口服糖耐量试验后2小时的血糖和高密度脂蛋白胆固醇预测了代谢综合征的发生(均p<0.05)。

简而言之,在PP晚期,MetS和糖尿病前期的患病率显著增加。根据研究结果,对产后糖尿病进行为期1年的筛查是绝对必要的。研究还确定了妊娠前和妊娠期间以及妊娠后期早期预测代谢综合征、肥胖或糖尿病前期的因素。针对这些因素的定向干预应在标准医疗护理的早期实施,并应在未来的干预试验中进行评估。

参考文献:Kosinski CRossel JGross J, et al. Adverse metabolic outcomes in the early and late postpartum after gestational diabetes are broader than glucose control.

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    2021-11-16 419040982

    好的!

    0

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