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Stroke:大血管闭塞性卒中快速和缓慢进展的发病率和时间分布

2019-06-20 国际循环编辑部 国际循环

临床实践中,经常观察到由于前循环大血管闭塞引起的梗死快速和缓慢进展。近日,Stroke杂志发表一项研究,旨在评估卒中发病后24 h内诊断出的前循环大血管闭塞患者快速和缓慢进展者的发病率和时间分布。

临床实践中,经常观察到由于前循环大血管闭塞引起的梗死快速和缓慢进展。近日,Stroke杂志发表一项研究,旨在评估卒中发病后24 h内诊断出的前循环大血管闭塞患者快速和缓慢进展者的发病率和时间分布。

这项单中心回顾性研究,纳入85例前循环大血管闭塞患者,在卒中发病后24 h内接受基线计算机断层扫描灌注或磁共振成像。确定快速进展者(缺血核心> 70 ml,卒中发作<6 h)和缓慢进展者(缺血核心≤30 ml,卒中发作> 6~24 h)的患病率。

结果显示,从卒中发作到基线核心成像的中位时间间隔为7.6 h(四分位间距为3.9~13.2),中位核心体积为17 ml(范围0~405)。在整个队列中,72%的患者核心体积≤70 ml。快速进展者的患病率为25%(95%CI:17%~37%),并且在卒中发病后3~4.5 h内达到40%(95%CI:24%~59%)。缓慢进展者的患病率为55%(95%CI:46%~64%),并且在卒中发病后6 h内的时间间隔相似。

研究表明,大部分前循环大血管闭塞患者具有中小型缺血核心体积,无论卒中发作后24h内是否出现早期或延迟。快速进展者在卒中发病后3~4.5 h内非常普遍。

原始出处:
Marcelo Rocha Shashvat M. Desai,Ashutosh P. Jadhav,Tudor G. Jovin,et al.Prevalence and Temporal Distribution of Fast and Slow Progressors of Infarct Growth in Large Vessel Occlusion Stroke.Stroke,June 2019.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1815193, encodeId=49991815193e4, content=<a href='/topic/show?id=5f519e1848c' target=_blank style='color:#2F92EE;'>#闭塞性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97184, encryptionId=5f519e1848c, topicName=闭塞性卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Thu Aug 08 18:44:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706141, encodeId=1bbf1e0614100, content=<a href='/topic/show?id=7f6443986ec' target=_blank style='color:#2F92EE;'>#大血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43986, encryptionId=7f6443986ec, topicName=大血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caff31165455, createdName=kkunny, createdTime=Thu Jan 16 09:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823565, encodeId=31b51823565f3, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Mon Apr 06 00:44:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009854, encodeId=599a2009854fb, content=<a href='/topic/show?id=467789803a9' target=_blank style='color:#2F92EE;'>#血管闭塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89803, encryptionId=467789803a9, topicName=血管闭塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Mon Feb 17 19:44:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026390, encodeId=98be102639081, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Jun 20 23:44:00 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
    2020-01-16 kkunny
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    2019-06-20 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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