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Oncogenesis:二甲双胍可以抑制SUV39H1调控的前列腺癌细胞迁移

2017-05-06 AlexYang MedSci原创

前列腺癌(PCa)是男性癌症相关死亡的主要原因,很大程度上是由于不能治愈的远距离转移。二甲双胍是一种广泛应用于抗糖尿病2型的药物,研究发现,该药能够减少癌症风险并且能取得更好的诊断最近,有研究人员发现,二甲双胍能抑制PCa细胞的迁移,而PCa细胞的迁移与肿瘤转移能力相关。发病机理和肿瘤进展与肿瘤细胞中基因的异常表达相关,主要是通过表观修饰,比如DNA甲基化和组蛋白修饰。研究人员发现,SUV39H

前列腺癌(PCa)是男性癌症相关死亡的主要原因,很大程度上是由于不能治愈的远距离转移。二甲双胍是一种广泛应用于抗糖尿病2型的药物,研究发现,该药能够减少癌症风险并且能取得更好的诊断

最近,有研究人员发现,二甲双胍能抑制PCa细胞的迁移,而PCa细胞的迁移与肿瘤转移能力相关。发病机理和肿瘤进展与肿瘤细胞中基因的异常表达相关,主要是通过表观修饰,比如DNA甲基化和组蛋白修饰。研究人员发现,SUV39H1(一个H3 Lys9的组蛋白甲基转移酶)的水平以时间依赖的方式在二甲双胍处理的PCa细胞减少了。SUV39H1的超表达可以增加PCa的迁移;与之相反,SUV39H1的缺失可以抑制PCa的迁移。SUV39H1的表达水平与PCa病理阶段呈正相关关系。研究进一步展示了二甲双胍处理和PCa细胞中的SUV39H1敲除可以减少αV 和 β1整合蛋白,同时,也可以降低它们的下游磷酸化的黏着斑激酶(FAK)水平,这些对功能性黏着信号和肿瘤细胞迁移非常重要。总之,二甲双胍可以通过干扰FAK信号整合蛋白,减少SUV39H1来抑制PCa细胞的迁移。最后,研究人员指出,SUV39H1可以作为一个抑制PCa细胞迁移的一个新的靶点。

原始出处:

T Yu, C Wang, J Yang et al. Metformin inhibits SUV39H1-mediated migration of prostate cancer cells. Oncogenesis. 01 May 2017.

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    2017-09-08 一叶知秋
  4. [GetPortalCommentsPageByObjectIdResponse(id=1640910, encodeId=41511640910b4, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Sat Mar 24 10:42:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077477, encodeId=3cd420e74779c, content=<a href='/topic/show?id=7d4716938b2' target=_blank style='color:#2F92EE;'>#Suv39h1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16938, encryptionId=7d4716938b2, topicName=Suv39h1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Sun Mar 18 13:42:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048826, encodeId=41f4204882686, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Sep 08 10:42:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197433, encodeId=2b1319e43392, content=学习了!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat May 13 07:50:36 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252239, encodeId=96bb1252239a0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529573, encodeId=dbbb15295e357, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d5e11955593, createdName=amy0554, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558071, encodeId=85fa15580e188, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588239, encodeId=319c1588239d9, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620208, encodeId=3c041620208d6, content=<a href='/topic/show?id=c62132549a5' target=_blank style='color:#2F92EE;'>#前列腺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32549, encryptionId=c62132549a5, topicName=前列腺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09820091072, createdName=lifestar, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-13 一个字-牛

    学习了!谢谢分享

    0

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    2017-05-08 yxch36
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1640910, encodeId=41511640910b4, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Sat Mar 24 10:42:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077477, encodeId=3cd420e74779c, content=<a href='/topic/show?id=7d4716938b2' target=_blank style='color:#2F92EE;'>#Suv39h1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16938, encryptionId=7d4716938b2, topicName=Suv39h1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Sun Mar 18 13:42:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048826, encodeId=41f4204882686, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Sep 08 10:42:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197433, encodeId=2b1319e43392, content=学习了!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat May 13 07:50:36 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252239, encodeId=96bb1252239a0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529573, encodeId=dbbb15295e357, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d5e11955593, createdName=amy0554, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558071, encodeId=85fa15580e188, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588239, encodeId=319c1588239d9, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620208, encodeId=3c041620208d6, content=<a href='/topic/show?id=c62132549a5' target=_blank style='color:#2F92EE;'>#前列腺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32549, encryptionId=c62132549a5, topicName=前列腺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09820091072, createdName=lifestar, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-08 zsyan
  8. [GetPortalCommentsPageByObjectIdResponse(id=1640910, encodeId=41511640910b4, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Sat Mar 24 10:42:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077477, encodeId=3cd420e74779c, content=<a href='/topic/show?id=7d4716938b2' target=_blank style='color:#2F92EE;'>#Suv39h1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16938, encryptionId=7d4716938b2, topicName=Suv39h1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Sun Mar 18 13:42:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048826, encodeId=41f4204882686, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Sep 08 10:42:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197433, encodeId=2b1319e43392, content=学习了!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat May 13 07:50:36 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252239, encodeId=96bb1252239a0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529573, encodeId=dbbb15295e357, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d5e11955593, createdName=amy0554, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558071, encodeId=85fa15580e188, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588239, encodeId=319c1588239d9, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620208, encodeId=3c041620208d6, content=<a href='/topic/show?id=c62132549a5' target=_blank style='color:#2F92EE;'>#前列腺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32549, encryptionId=c62132549a5, topicName=前列腺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09820091072, createdName=lifestar, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-08 skhzy
  9. [GetPortalCommentsPageByObjectIdResponse(id=1640910, encodeId=41511640910b4, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Sat Mar 24 10:42:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077477, encodeId=3cd420e74779c, content=<a href='/topic/show?id=7d4716938b2' target=_blank style='color:#2F92EE;'>#Suv39h1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16938, encryptionId=7d4716938b2, topicName=Suv39h1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Sun Mar 18 13:42:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048826, encodeId=41f4204882686, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Sep 08 10:42:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197433, encodeId=2b1319e43392, content=学习了!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat May 13 07:50:36 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252239, encodeId=96bb1252239a0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529573, encodeId=dbbb15295e357, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d5e11955593, createdName=amy0554, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558071, encodeId=85fa15580e188, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588239, encodeId=319c1588239d9, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620208, encodeId=3c041620208d6, content=<a href='/topic/show?id=c62132549a5' target=_blank style='color:#2F92EE;'>#前列腺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32549, encryptionId=c62132549a5, topicName=前列腺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09820091072, createdName=lifestar, createdTime=Mon May 08 04:42:00 CST 2017, time=2017-05-08, status=1, ipAttribution=)]

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前列腺癌外显子组和基因组的下一代测序鉴定了大量的遗传变异位点。SPOP(斑点型POZ蛋白)是初级前列腺癌中最经常发生突变的基因之一,表明了SPOP是一个前列腺癌发生和发展的潜在驱使因子。然而,SPOP图片怎样导致前列腺癌的发病机理仍旧所知甚少。SPOP可以作为CUL3-RBX1 E3泛素连接酶复合物的接头蛋白并且可以招募泛素化底物以便随后的降解。内质网定位的甲酸精蛋白倒甲酸精2(INF2)可以调控

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雄激素受体在前列腺癌的发展中起着非常重要的作用,通过雄激素剥夺治疗来抑制雄激素受体成为转移性前列腺癌的起始治疗。大部分病人,对雄激素剥夺治疗会有反应,但是随后这部分病人会表现出不同形式的复发及出现去势抵抗性前列腺癌。现在已经清楚是雄激素受体通过增加表达及扩增在去势抵抗性前列腺癌中仍起驱动作用。使得雄激素受体在去势抵抗中起作用的另一机理,即通过肾上腺中的前体类固醇使得瘤内合成雄激素(睾酮或二氢睾酮)

Prostate Cancer P D:机器人辅助的根治性前列腺癌切除术治疗临床高风险前列腺癌病人的功能恢复

最近,研究人员评估了机器人辅助的根治性前列腺癌切除术(RARP)治疗临床高风险前列腺癌病人(PCa)的3年排尿控制(UC)和性功能(SF)恢复状况。2001年和2004年,研究人员对美国和欧洲的两个三级医疗中心维护的数据库,即769名患有D'Amico高风险PCa并且经历RARP的病人资料,进行了回顾性分析。研究人员分别利用术前和术后Cox比例风险回归模型对从RARP与UC和SF的恢复的时间关系进

Prostate Cancer P D:前列腺切除术后的补救放射疗法后,受益于雄激素阻断治疗的选择的男性

对于哪一名男性能够在前列腺切除术后补救放射疗法(SRT)中加入雄激素阻断治疗(ADT)受益最大,人们对这个问题仍旧不清楚。最近,有研究人员评估了ADT对SRT在前列腺切除术后具有增加的或者永久PSA男性的成功生存率(FFS)的影响。研究人员鉴定了在1987年到2010年,前列腺切除术后接受SRT的男性患者,并根据单个的SRT后失败的风险,利用独立递归分级指数(RPA)鉴定了有利的、中间的和不利的小

CLIN CANCER RES:前列腺切除术前新辅助Enzalutamide治疗

前列腺癌需要雄激素受体活化。理想的雄激素受体拮抗作用可以有效缩小局部病灶并抑制或清除微转移灶。CLIN CANCER RES近期发表了一篇文章,研究前列腺切除术前雄激素受体拮抗剂enzalutamide(enza)单独或与dutasteride(dut)及leuprolide联合新辅助治疗(enza/dut/LHRHa)的疗效。

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