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Crit Care Med:输注红细胞,对失血性休克患者的舌下微循环有什么影响?

2016-10-15 MedSci MedSci原创

红细胞输注对微血管灌注的影响并没有得到很好的研究。我们对失血性休克患者进行了本项前瞻性、初步观察研究,评估红细胞输注对舌下微循环的影响。 研究地点为一所大学医院里28张床的外科重症监护病房。纳入了15例失血性休克患者,需要红细胞输注。研究干预为一个单位的红细胞输注。 在红细胞输注前后,使用侧流暗场成像装置评估患者的舌下微循环情况。输注一个单位的红细胞后,血红蛋白浓度从8.5 g/dL

红细胞输注对微血管灌注的影响并没有得到很好的研究。我们对失血性休克患者进行了本项前瞻性、初步观察研究,评估红细胞输注对舌下微循环的影响。

研究地点为一所大学医院里28张床的外科重症监护病房。纳入了15例失血性休克患者,需要红细胞输注。研究干预为一个单位的红细胞输注。

在红细胞输注前后,使用侧流暗场成像装置评估患者的舌下微循环情况。输注一个单位的红细胞后,血红蛋白浓度从8.5 g/dL (7.6-9.5 g/dL)增加至9.6 g/dL (9.1-10.3 g/dL) g/dL (p = 0.02),但是对大循环参数(动脉压、心脏指数、心率和脉压变化)没有影响。

输注红细胞可显著增加微循环血流指数(从2.3 [1.6-2.5]到2.7 [2.6-2.9]; p < 0.003)、灌注血管比例(从79% [57-88%]到92% [88-97%]; p < 0.004)和毛细血管密度(从21 [19-22]到24 [22-26] mm/mm2; p = 0.003)。输注红细胞可显著减少血流异质性指数(从0.51 [0.34-0.62]到0.16 [0.04-0.29]; p < 0.001)。输血与其他大血管和微血管参数的变化无关。输注后微血管灌注的变化与基线微血管灌注呈负相关。

结果表明,输注红细胞可以改善失血性休克患者的舌下微循环,独立于大循环和血红蛋白水平。输注后微血管灌注的变化与基线微血管灌注呈负相关。评估微循环灌注是优化微血管灌注的关键,并确定心血管复苏过程中哪些患者可以受益于红细胞输注。

原始出处:

Tanaka, Sebastien,et al.Effect of RBC Transfusion on Sublingual Microcirculation in Hemorrhagic Shock Patients: A Pilot Study.Critical Care Medicine.September 15, 2016

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    2016-11-13 yyj062
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    2016-10-17 kord1982
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    2016-10-17 daviiliu
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