BRAIN：精神分裂症中异常纹状体多巴胺在构造上与皮质-丘脑功能不全相关

2020-12-31 MedSci原创 MedSci原创

在精神分裂症患者中，背侧纹状体的多巴胺功能异常以及不同皮质网络和丘脑核团之间的异常固有功能连接(IFC)是最一致的大规模脑影像学发现。

在精神分裂症患者中，背侧纹状体的多巴胺功能异常以及不同皮质网络和丘脑核团之间的异常固有功能连接(IFC)是最一致的大规模脑影像学发现。这两种变化之间的病理生理联系是由基于纹状体多巴胺对皮质-基底神经节-丘脑回路内皮质-丘脑连接性的地形调制的理论模型提出的。我们假设异常的纹状体多巴胺在地形上与异常的皮质-丘脑iFC相连，即异常的关联性纹状体多巴胺与显著性网络和丘脑之间的异常iFC相关联，异常的感觉运动性纹状体多巴胺与听觉-感觉器之间的异常iFC相关。本研究过程中，19名精神病症状缓解期间的精神分裂症患者和19名年龄和性别可比的对照受试者同时接受了氟二羟苯基-1-丙氨酸PET（18F-DOPA-PET）和静息状态功能MRI（rs-fMRI）。以18F-DOPA-PET为基础的潮气恒定消散剂用于测量纹状体多巴胺的合成能力。皮质网络的rs-fMRI时间序列与感兴趣的丘脑区域之间的相关系数用于测量iFC。在以显著网络为中心的系统中，患者的纹状体多巴胺合成能力降低，这与显著网络-中枢-丘脑iFC降低呈正相关。这种相关性在患者和健康对照组中均存在。在以听觉-感觉运动网络为中心的系统中，患者的感觉运动纹状体多巴胺合成能力降低，与听觉-感觉运动网络-腹侧丘脑iFC的增加呈正相关。这种相关性仅存在于患者中。结果表明，减少的纹状体多巴胺合成能力在地形上与精神分裂症中的皮质-丘脑固有失联有关。数据表明，精神分裂症中多巴胺调节的皮质-基底神经节-丘脑回路中异常的纹状体多巴胺和皮质-丘脑功能失调是病理生理相关的。

原文出处：

Mihai Avram, Felix Brandl, Franziska Knolle, Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia.

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2021-01-02 1209e435m98(暂无昵称)

学习了，谢谢分享

102 0
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2021-01-02 heli0118

#精神分裂#

44 0
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2021-01-02 医者仁心

#脑功能#

60 0
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2021-01-02 xlwang2696

#丘脑#

50 0
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2021-01-02 xlwang2696

#丘脑#

48 0
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2021-01-01 屹起成长

已学习

105 0
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2021-01-01 13c30453m58暂无昵称

学习了

85 0
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2021-01-01 xlsh2468

牛牛

90 0

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