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Arthritis Rheumatol:膝关节软骨钙化与骨关节炎进展的风险

2019-12-07 xiangting MedSci原创

在症状性KOA患者中,存在膝关节CC并不影响5年时关节置换术或疾病进展的风险。

这项研究旨在评估膝关节骨关节炎(KOA)患者中,膝关节软骨钙化(CC)对关节置换和疾病进展5年风险的影响。

KHOALA队列招募既往没有进行过全关节(膝或髋)置换(TJR)的症状性KOA患者。使用Cox比例风险回归和广义估计方程模型比较膝关节CC患者与无CC患者从入组或OA诊断到全膝关节置换(TKR)或TJR的时间。对于无偶发性TKR患者,进行logistic回归以分析第0年与第5年间CC与影像学进展(Kellgren-Lawrence [KL]分级)或西安大略和麦克马斯特大学骨关节炎指数(WOMAC)OA疼痛或功能评分恶化之间的关联。估算危险比(HRs)和95%置信区间(CIs)。分析对年龄、性别、体重指数、WOMAC评分和KL分级进行调整。

纳入656例患者,其中93例(14.2%)患有膝关节CC,随访期间91(13.9%)接受了TKR。存在膝关节CC不影响TKR的风险(HR 1.26; 95CI 0.74-2.17)。偶发性TJR风险的结果类似(HR 1.14 0.68-1.92)。对于无偶发性TKR患者,膝关节CC不影响KL分级(OR 0.9; 0.4-1.7)或WOMAC疼痛(OR 1.10.7-1.4/功能评分(OR 0.9; 0.4-2.0)恶化的风险。

在症状性KOA患者中,存在膝关节CC并不影响5年时关节置换术或疾病进展的风险。

原始出处:

Augustin Latourte. Chondrocalcinosis of the knee and the risk for osteoarthritis progression: data from the KHOALA cohort. Arthritis Rheumatol. 05 December 2019.

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    2020-01-23 lisa438
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    2020-04-11 anan
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    2019-12-09 lmm397
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    2019-12-09 zhaojie88

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