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Gastroenterology:青少年乳糜泻发病率的长期研究

2017-05-08 zhangfan MedSci原创

对于10岁以下的少年儿童,自身免疫腹腔疾病和乳糜泻的累积发病率很高,虽然超过5%的儿童可能会发生自身免疫腹腔疾病,但并非所有的儿童都会发展为乳糜泻或要求无麸质饮食

近日,研究人员就丹佛地区青少年乳糜泻发病率进行了研究

研究人员以1993年至2004年间出生的31766名婴儿为研究对象,估计其中乳糜泻的发病率。对参试者进行组织转谷氨酰胺酶自身抗体(tTGA)检测确定腹腔自身免疫疾病(CDA)或乳糜泻。研究对于每个基因型的CDA和乳糜泻的累积发病率进行了测定并根据这些基因型在一般人群中的频率估计在丹佛地区总累积发病率。

对1339名儿童的随访发现,有66名自身免疫并伴乳糜泻的患者以及46名单纯自身免疫腹腔疾病患者, 其中21名(46%)单纯自身免疫腹腔疾病患者,tTGA抗体阳性可自行消除。5岁、10岁和15岁的儿童CDA的累积发病率为2.4%、4.3%和5.1%,乳糜泻发病率为1.6%、 2.8%和3.1%。

研究发现对于10岁以下的少年儿童,自身免疫腹腔疾病和乳糜泻的累积发病率很高,虽然超过5%的儿童可能会发生自身免疫腹腔疾病,但并非所有的儿童都会发展为乳糜泻或要求无麸质饮食。

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    2017-12-21 许安
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    2017-05-20 I come

    学习了,谢谢分享

    0

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    2017-05-08 明月清辉

    谢谢分享,学习了

    0

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