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Allergy:在青少年和成年人中,哮喘-鼻炎多重病症与lgE多重致敏相关

2018-01-23 AlexYang MedSci原创

患有多重病症哮喘和鼻炎的儿童表现出了对几种过敏原同时的lgE多重致敏特性,但是多重病症与多重致敏之间的相关性在青少年和成年人中缺乏相关研究。最近,有研究人员在成年人和青少年中,调查了lgE对一个广泛气源性过敏原组分的敏化模式情况,并且重点关注了具有哮喘和鼻炎多重病症的个体。研究包括了EGEA(n=840, 年龄为40.7±17.1)和BAMSE(n=786, 年龄为16±0.26)2个群体,参与者

患有多重病症哮喘和鼻炎的儿童表现出了对几种过敏原同时的lgE多重致敏特性,但是多重病症与多重致敏之间的相关性在青少年和成年人中缺乏相关研究。最近,有研究人员在成年人和青少年中,调查了lgE对一个广泛气源性过敏原组分的敏化模式情况,并且重点关注了具有哮喘和鼻炎多重病症的个体。

研究包括了EGEA(n=840, 年龄为40.7±17.1)和BAMSE(n=786, 年龄为16±0.26)2个群体,参与者可以分为4种表型:没有哮喘和鼻炎((A-R-; 30% in EGEA和54% in BAMSE),只有哮喘(A+R-; 11%和8%),只有鼻炎(A-R+; 15%和24%)和同时患有哮喘和鼻炎(A+R+; 44%和14%)。研究发现,lgE反应的气源性过敏原分子数在不同表型组之间具有显著差异(在 A-R-, A+R-, A-R+ 和A+R+中: 0, 1, 2和7 in EGEA 以及0, 0, 3和 5 in BAMSE)。与A-R-受试者相比,lgE反应的平均分子数的调整后比例要比A+R+更高。最后,研究人员指出,A+R+表型组合了A+R-和A-R+的敏化模式,并且该多重病症多重致敏表型似乎可以推广到各种年龄和过敏环境,这也许与特殊的机制有关。

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    2018-01-25 膀胱癌
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    2018-01-25 HNYYM
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    2018-01-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-01-24 飛歌

    厉害了我的哥

    0

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    2018-01-23 有备才能无患

    患有多重病症哮喘和鼻炎的儿童表现出了对几种过敏原同时的lgE多重致敏特性.但是多重病症与多重致敏之间的相关性在青少年和成年人中缺乏相关研究.最近.有研究人员在成年人和青少年中.调查了lgE对一个广泛气源性过敏原组分的敏化模式情况.并且重点关注了具有哮喘和鼻炎多重病症的个体.

    0

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