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Stroke:青年先天性心脏病患者出血性卒中的长期风险!

2018-04-08 xing.T MedSci原创

由此可见,CHD儿童和年轻人发生出血性卒中的相对风险几乎是一般人群的8倍,尽管绝对风险较低。重症非圆锥动脉干缺陷或主动脉缩窄患者发生ICH和SAH的风险最高。

先天性心脏病(CHD)患者缺血性卒中的风险增加;然而,出血性脑卒中,包括脑出血(ICH)和蛛网膜下腔出血(SAH),的风险数据较为缺乏。

近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员通过瑞典患者登记中心确定了1970年至1993年期间诊断为CHD的患者。每个患者与从一般人群中随机选择的10个对照者进行比较,并对年龄、性别和县市进行匹配。随访至2011年12月收集病例和对照者数据。

该研究共招募了21982例CHD患者,随访年龄至42岁,70例受试者发生ICH和57例受试者发生SAH。相比于对照者,CHD患者发生ICH的风险增加8倍(发病率为8.23;95%可信区间为6-11.2),发生SAH的风险增加8倍(发病率为7.64;95%可信区间为5.41–10.7)。ICH和SAH的绝对风险很低,发生率分别为1.18人和0.96人每10000人每年。重症非圆锥动脉干缺陷的患者(发病率为16.5;95%可信区间为5.63–51.2)或主动脉缩窄(发病率为17.3;95%可信区间为6.63–51.8)发生出血性脑卒中的相对风险最高,发生率分别为3.22人和2.79人每10000人每年。

由此可见,CHD儿童和年轻人发生出血性卒中的相对风险几乎是一般人群的8倍,尽管绝对风险较低。重症非圆锥动脉干缺陷或主动脉缩窄患者发生ICH和SAH的风险最高。

原始出处:

Kok Wai Giang,et al. Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease.Stroke. 2018. https://doi.org/10.1161/STROKEAHA.117.020032

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    2018-04-10 huirong
  3. [GetPortalCommentsPageByObjectIdResponse(id=1319561, encodeId=3abd131956169, content=<a href='/topic/show?id=1dc13145ef8' target=_blank style='color:#2F92EE;'>#出血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31457, encryptionId=1dc13145ef8, topicName=出血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Tue Apr 10 10:51:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369359, encodeId=9eaf1369359d9, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Tue Apr 10 10:51:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401338, encodeId=745e1401338af, content=<a href='/topic/show?id=80e89e0479a' target=_blank style='color:#2F92EE;'>#长期风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97047, encryptionId=80e89e0479a, topicName=长期风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Apr 10 10:51:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026007, encodeId=48f4102600eb8, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Apr 08 22:51:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303965, encodeId=4698303965d9, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sun Apr 08 20:28:46 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
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    2018-04-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2018-04-08 wqkm

    ^_^^_^^_^

    0

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