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Neurology:儿童和青年创伤后缺血性卒中风险分析!

2017-11-09 xing.T MedSci原创

由此可见,创伤后2周内发生卒中的风险升高。起病经常延迟,这为卒中预防提供了一个机会。然而,在创伤时,约有1/4的卒中患者在脑血管成像检查中没有发现血管异常。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,研究人员旨在一个以人群为基础的年轻人队列中来量化创伤后缺血性卒中的发生率、时机和风险。

研究人员从加利福尼亚州北部综合医疗保健系统(1997-2011)登记的人群中以电子方式确定了创伤患者(<50岁)。在这一队列中,研究人员确定了创伤后4周内发生动脉缺血性卒中病例,并每个患者匹配3个对照者。一个由医生组成的小组来审查医疗记录对病例进行确认,以确定与创伤相关的卒中。研究人员计算了4周内卒中的发生率,并且采用Logistic回归根据创伤位置估计了卒中的比值比(OR)。

从1308009例创伤病例中,研究人员确认了52例创伤相关的缺血性卒中患者。4周内脑卒中的发病率为每100000人中有4名(95%可信区间[CI]为3-5.2)。26例患者为多系统创伤(50%)。19例(37%)患者卒中发生在创伤当天,所有卒中发生在创伤15天之内。在创伤时,进行脑血管成像检查的28例患者有7例未检测到异常。在未经调整的分析中,头部、颈部、胸部、背部、腹部损伤会增加卒中风险。只有头部(OR为4.1,95%CI为1.1-14.9)和颈部(OR为5.6,95%CI为1.03-30.9)损伤仍然与卒中相关,在调整了人口学特征和创伤严重程度的标志(多系统创伤、车辆碰撞、救护车、插管)。

由此可见,创伤后2周内发生卒中的风险升高。起病经常延迟,这为卒中预防提供了一个机会。然而,在创伤时,约有1/4的卒中患者在脑血管成像检查中没有发现血管异常。

原始出处:

Christine K. Fox,et al. Population-based study of ischemic stroke risk after trauma in children and young adults.Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000004708

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    2018-04-20 yinhl1978
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    2017-11-09 1ddf0692m34(暂无匿称)

    学习了.涨知识

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