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Int J Cardiol:儿童感染性心内膜炎以及血栓栓塞并发症的发生率分析!

2017-11-08 xing.T MedSci原创

在研究期间,研究人员报道了在年龄较大的儿童中社区获得性IE的发病率正在上升,同时TEC的发病率也在上升。心力衰竭和赘生物与死亡率增加有关,这些初步数据需要通过前瞻性数据来确认。

儿科感染性心内膜炎(IE)与高发病率和死亡率相关,大部分与血栓栓塞性并发症(TEC)有关。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员旨在描述IE患儿的经历,并回顾三十年来IE的来源、赘生物发生率、TEC及其各自的发病率和死亡率的变化。

研究人员对符合杜克标准的0-18岁入住儿童医院的儿童进行了回顾性病历分析。数据分为三个阶段(P):P1(1979-1988)、P2(1989-1998)和P3(1999-2008)。

该研究纳入了113名患者,平均年龄为7岁。女性占46(41%),先天性心脏缺陷患者有95例(84%)。总体而言,113例患者中有68例(60%)发生了心脏赘生物,32例(28%)患者出现了较大的心脏赘生物(≥1cm)。有45例患者发生TEC(45/133[40%]),22例(20%)患者发生脑血管事件(CVE),23例(20%)患者发生非CVE。P3期间诊断的患者年龄较大,赘生物更多(P<0.05),社区获得性IE发生率更高(p <0.05)。总的来说,所有时期死亡率为15%。死亡的显著危险因素为赘生物(风险比为6.44; 95%可信区间为2.07-20.01,P=0.002)和心力衰竭(风险比为28.39; 95%可信区间为10.49-76.85,P<0.001)。

在研究期间,研究人员报道了在年龄较大的儿童中社区获得性IE的发病率正在上升,同时TEC的发病率也在上升。心力衰竭和赘生物与死亡率增加有关,这些初步数据需要通过前瞻性数据来确认。

原始出处:

K. Thoma, d,et al. Incidence of infective endocarditis and its thromboembolic complications in a pediatric population over 30 years.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2017.10.085

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time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259768, encodeId=66d9259e6836, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 08 17:50:43 CST 2017, time=2017-11-08, status=1, ipAttribution=)]
  6. 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time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259768, encodeId=66d9259e6836, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 08 17:50:43 CST 2017, time=2017-11-08, status=1, ipAttribution=)]
    2018-03-07 丁鹏鹏
  7. 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time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259768, encodeId=66d9259e6836, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 08 17:50:43 CST 2017, time=2017-11-08, status=1, ipAttribution=)]
    2017-12-04 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  8. 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  9. 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time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259768, encodeId=66d9259e6836, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 08 17:50:43 CST 2017, time=2017-11-08, status=1, ipAttribution=)]
    2017-11-08 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

  10. 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CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350691, encodeId=7c1013506918d, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Nov 10 08:19:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259776, encodeId=ede1259e76b4, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Nov 08 19:37:21 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259768, encodeId=66d9259e6836, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 08 17:50:43 CST 2017, time=2017-11-08, status=1, ipAttribution=)]
    2017-11-08 中医痴

    不错了.学习了.谢谢分享!

    0

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