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JAMA:术前卵圆孔未闭是重要的围手术期中风风险因素

2018-02-07 zhangfan MedSci原创

研究认为,术前卵圆孔未闭是重要的围手术期中风风险因素

围手术期卒中是手术患者的主要并发症。卵圆孔未闭(PFO)、静脉血栓与脑卒中存在一定关联。近日研究人员就术前PFO与围手术期缺血性脑卒中之间的关系进行了考察。

接受全麻的非心脏手术成年患者参与研究,术前进行PFO检查。研究的主要终点为术后30天中风发病率,中风亚型根据牛津分类划分,中风严重程度根据NIHSS评分确定。

150198名患者参与研究,平均年龄55岁,其中1540人(1.0%)术前诊断PFO,850人中风发病(0.6%),其中PFO患者中风患者49人(3.2%),非PFO患者中风患者801人(0.5%)。调整分析后,PFO显著增加患者术后中风风险(OR,2.66,95% CI,1.96-3.63)。每100名PFO患者术后中风发病5.9人,而非PFO仅为2.2人 (绝对风险差异为0.4%,95% CI,0.2%-0.6%)。PFO患者术后大面积中风风险增加(rr, 3.14,95% CI,2.21-4.48),NIHSS卒中相关神经功能缺损更为严重(PFO患者平均NIHSS得分 4;非PFO患者得分3)。

研究认为,术前卵圆孔未闭是重要的围手术期中风风险因素。

原始出处:


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    2018-02-09 jihuaijun1112

    学习学习学习学习

    0

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    2018-02-07 虈亣靌

    学习了受益匪浅

    0

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    2018-02-07 龙胆草

    学习谢谢分享

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    2018-02-07 jihuaijun1112

    学习学习学习学习

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