内免疫疗法的信心！我国生物技术公司ICT CAR-T治疗B淋巴细胞白血病治愈率达90%

2016-05-10 佚名生物谷

图片来源：http://www.biospace.com 4月22日至24日，2016年血液病免疫治疗峰会在杭州召开。来自浙江大学附属第一医院的黄河教授首次公开了10个CAR-T治疗白血病的临床病例数据，成果非常喜人。该临床试验是由浙江大学附属第一医院协同生物技术公司Innovative Cellular Therapeutics (ICT)联合实施的，2015年6月份通过伦理委员会批准

图片来源：http://www.biospace.com

4月22日至24日，2016年血液病免疫治疗峰会在杭州召开。来自浙江大学附属第一医院的黄河教授首次公开了10个CAR-T治疗白血病的临床病例数据，成果非常喜人。

该临床试验是由浙江大学附属第一医院协同生物技术公司Innovative Cellular Therapeutics (ICT)联合实施的，2015年6月份通过伦理委员会批准，接受了首例患者。到2016年4月，第十名患者获得了完全缓解。在为期10个月的临床试验中，黄河研究团队为这10名复发或难治性B淋巴细胞白血病患者进行了CAR-T细胞治疗，并初步评估其安全性和有效性。

该临床试验严格符合临床伦理标准，并由第三方临床研究机构监督。所有接受CAR-T治疗的患者产生的医疗费用由Innovative Cellular Therapeutics (ICT)公司承担。试验结果表明，9名患者获得了完全缓解，8名患者的白血病微小残留病（minimal residual disease，MRD）转为阴性，这是CAR-T治疗取得疗效的重要标志。白血病微小残留病，是指在白血病经诱导化疗获完全缓解后或是骨髓移植治疗后，体内仍雍留有少量白血病细胞的状态，可作为预后的一个指标。90%的完全缓解率、80%的MRD阴性率，这是迄今为止世界上用CAR-T治疗B淋巴细胞白血病得到的最佳结果。

这10名参与临床治疗的患者，年龄从17岁至57岁，全部患有复发或难治性B淋巴细胞白血病，接受治疗前，生命只剩下短短的几个月。参与临床治疗的第十名患者年仅17岁，她于今年3月份决定接受CAR-T治疗。黄河研究团队从她的血液中分离出T细胞，并对其进行基因工程改造，使其表达嵌合抗原受体，也就是所谓的“CAR”。表达嵌合抗原受体的T细胞能够准确识别和消灭恶性肿瘤细胞，从而达到治疗癌症的目的。随后4月份，CAR-T细胞被重新输入患者体内，接着就发生了“细胞因子风暴”，这是研究人员预期的结果。由于CAR-T细胞在患者体内快速增殖，机体会释放大量的细胞因子，患者会出现发热、肌肉疼痛和血氧不足等症状，这表明CAR-T细胞在体内发挥了作用。最终结果是这名17岁的患者获得了完全缓解，其白血病微小残留病也转为阴性。

Innovative Cellular Therapeutics公司除了与浙江大学第一附属医院进行合作之外，还与其它7家医院展开了复发和难治性急性淋巴细胞白血病的CAR-T治疗临床试验，目前这部分临床试验已经完成，得到了23名患者的原始数据。这23名患者中，有20名得到了完全缓解，完全缓解率达到87%。

在此之前，全世界只有诺华、Juno和Kite Pharma这三家美国公司在白血病中开展了类似的CAR-T治疗。这次临床试验成功标志着Innovative Cellular Therapeutics在CAR-T治疗白血病方面达到了世界领先水平。接下来，Innovative Cellular Therapeutics还将开展CAR-T治疗淋巴瘤的临床试验。随后Innovative Cellular Therapeutics将把目光投向结直肠癌、胃癌、食道癌等实体瘤领域。

近年来，CAR-T治疗已经受到医生、研究人员和患者的充分关注，作为一项精准的肿瘤免疫疗法，相信会在未来使得更多的肿瘤患者受益。谈到这里，生物谷小编想补充的是，这则消息许多外媒纷纷进行了报道，而国内却鲜有报道，不知是否受到了“魏则西事件”的影响。肿瘤免疫治疗在世界范围内方兴未艾，国内许多研究团队已经取得了一些成绩，例如李宗海教授的研究团队在恶性胶质瘤中进行的CAR-T治疗已经取得了喜人的成果。“魏则西事件”的黑锅不应当让肿瘤免疫疗法来背，人们需要相信国内科学家做出的努力，而不能让这一负面消息限制肿瘤免疫疗法在国内的发展。

原始出处：

Innovative Cellular Therapeutics Co.， Ltd. Release： Complete Remission Rate of 90： China-based CAR-T Cell Therapy Achieves Breakthrough Clinical Trial Results.2016.5.6

相关会议推荐

2016（第七届）细胞治疗国际研讨会

会议时间：2016.06.17-2016.06.18 会议地点：武汉

会议详情： http://www.bioon.com/z/2016Cell-therapies/

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2016-05-23 cenghis

#治愈率#

83 0
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2016-08-09 仁者大医

#CAR-#

75 0
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2016-12-29 ms3830150583600765

#B淋巴细胞白血病#

0 0
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2016-05-21 fengting15

#B淋巴细胞#

78 0
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2017-03-30 xlysu

#生物技术#

69 0
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2016-06-20 仁者大医

#淋巴细胞白血病#

59 0
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2016-05-21 1deccd6bm00(暂无匿称)

值得关注

169 0
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2016-05-12 wetgdt

#淋巴细胞#

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