日研究首次弄清了非酒精性脂肪肝的发病机制

2012-07-09 庄云芳新华网

文献标题:Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling文献来源:Cell Metabolism 2012 july ;16(1):44-54    &nb

文献标题:Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling
文献来源:Cell Metabolism 2012 july ;16(1):44-54

日本横滨市立大学和大阪大学的联合研究小组４日宣布，他们首次弄清了非酒精性脂肪肝的发病机制。他们确认，一些肥胖者的肝脏会与肠内的细菌发生过敏反应，从而导致肝部发病。

图：正常肝脏状态

非酒精性脂肪肝多由肥胖引起。它是指患者无饮酒史，但病理学上和酒精性脂肪肝患者有相似的病理状态，比如也有肝细胞脂肪变性、肝小叶炎症，有时也有“酒精”玻璃样变性和肝纤维化等。

研究人员在动物实验中发现，实验鼠肥胖后，脂肪细胞大量分泌的肥胖基因编码产物Leptin会发挥作用，促使肝脏对肠内细菌分泌的毒素脂多糖发生过敏反应，从而导致肝部疾病。

横滨市立大学教授中岛淳说：“如同花粉症患者一样，肥胖者会对细菌发生过敏反应，这一发现将有助于开发新的诊疗方法。

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2014-03-12 liuliangying

学习了，如果附有这方面的文献链接就好了。

135 0
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2013-01-04 yangshch

#酒精性脂肪肝#

77 0
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2012-08-22 huiwelcome

#酒精性#

87 0
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2012-10-18 Tommy1958

#非酒精性#

64 0

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日研究首次弄清了非酒精性脂肪肝的发病机制

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